Young Investigator Grants

Young Investigator grants are designed to fill the critical need for startup funds for less experienced researchers to pursue promising research ideas. Eligible applicants may apply during their fellowship training or early in their research careers but must not have achieved an appointment higher than Instructor. These grants encourage and cultivate the best and brightest researchers of the future and lead to long-term research projects. The Young Investigator grant offers up to $60,000 per year for three years.

Dana-Farber Cancer Institute

Background

Principal Investigator Name:

Cecile Rouleau, PhD

Project Title:

Identifying Disease Mechanisms and Therapeutic Opportunities in Pediatric Low-grade Gliomas Driven by MYB-QKI Fusions

Year Awarded:

2017

Cancer Research Category:

Brain Tumors

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

Dana-Farber Cancer Institute

Columbia Institute for Cancer Genetics

Background

Principal Investigator Name:

Shuobo Boboila, PhD

Project Title:

Development of Novel Biomarkers for Immunotherapy in Neuroblastoma

Year Awarded:

2017

Cancer Research Category:

Neuroblastoma

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

Columbia Institute for Cancer Genetics

Boston Children's Hospital

Background

Principal Investigator Name:

Anne Robertson, PhD

Project Title:

Understanding the Mechanisms of HOX Gene Regulation in Normal and Leukemic Hematopoietic Stem Cells to Identify New Therapies for Pediatric AML

Year Awarded:

2017

Cancer Research Category:

Acute Myeloid Leukemia (AML)

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

Boston Children’s Hospital

Boston Children's Hospital

Background

Principal Investigator Name:

Shuibin Lin, PhD

Project Title:

Role of N6-Methyladenosine (m6A) mRNA Modification Pathway in Neuroblastoma

Year Awarded:

2017

Cancer Research Category:

Neuroblastoma

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

Boston Children’s Hospital

Young Investigator Grant

Monday, December 11, 2023 - 12:00am

Young Investigator Grants

Nationwide Children's Hospital

The aim of this project is to define the effects of blocking E2A-PBX1 expression in a leukemia cell line containing the E2A-PBX1 translocation. Specifically we propose to study the effects of E2A-PBX1siRNA on growth and viability (aim 1) and whole genome gene expression (aim 2). Lastly, genes identified as having altered expression by siRNA will be compared to the previously published expression profile of E2A-PBX1 containing leukemias (aim 3).

Principal Investigator Name:

Mary Beth Ross, MD/PhD

Year Awarded:

2006

Cancer Research Category:

Leukemia

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

Research Institute at Nationwide Children's Hospital

Exosomes as Biomarkers to Monitor Disease Progression and Response to Therapy in Ewing sarcoma

Background

Principal Investigator Name:

Glenson Samuel, MD

Project Title:

Exosomes as Biomarkers to Monitor Disease Progression and Response to Therapy in Ewing sarcoma

Year Awarded:

2014

Cancer Research Category:

Ewing Sarcoma

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

Children’s Mercy

The Children's Hospital of Philadelphia

2016: Jennifer Wilkes is now employed at Seattle Children's Hospital and Regional Medical Center

Project Goal

Principal Investigator Name:

Jennifer Wilkes, MD

Project Title:

Hospital Volume and Induction Mortality in Children, Adolescents, and Young Adults with Acute Leukemia

Year Awarded:

2014

Cancer Research Category:

Leukemia

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

Children’s Hospital of Philadelphia

Files:

2016 paper_Volume Outcome Relationships in Pediatric Acute Lymphoblastic Leukemia

Baylor College of Medicine

Background

Using the patient's own immune system to fight cancers is a promising approach to improve outcomes for pediatric cancer patients who do not benefit from current therapies. However, the body's immune defenses against cancers often fail because the cancers do not induce or actively inhibit immunity. Cancer treatments consisting of the infusion of T cells (one component of the patient's own immune system) that recognize CD19, a molecule present on many blood cancers, have shown promise in early clinical studies.

Project Goal

Principal Investigator Name:

Mireya Paulina Velasquez, MD

Project Title:

Optimizing Engager T-cells for CD19+ Malignancies

Year Awarded:

2014

Cancer Research Category:

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

Baylor College of Medicine

Files:

velasquez_nature_scientific_reports_2016.pdf

Fred Hutchinson Cancer Research Center

Background

The mutation FLT3/ITD is common in acute myeloid leukemia (AML) and results in over-activation of cell signaling causing enhanced cell proliferation and survival. Patients with FLT3/ITD have a poor prognosis. The role of FLT3 inhibitors as targeted therapy is currently being evaluated in children and adults with AML. Despite an initial response, many patients relapse as the leukemic cells develop new mechanisms to survive and resist the effects of the targeted therapy. This group of patients has very few treatment options and very poor survival.

Principal Investigator Name:

Katherine Tarlock, MD

Project Title:

Identification of Resistance Mechanisms and Novel Therapeutic Strategies in Tyrosine Kinase Inhibitor Resistant FLT3/ITD Acute Myeloid Leukemia

Year Awarded:

2014

Cancer Research Category:

Leukemia

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

Fred Hutchinson Cancer Research Center

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