Young Investigator Grants

Young Investigator grants are designed to fill the critical need for startup funds for less experienced researchers to pursue promising research ideas. Eligible applicants may apply during their fellowship training or early in their research careers but must not have achieved an appointment higher than Instructor. These grants encourage and cultivate the best and brightest researchers of the future and lead to long-term research projects. The Young Investigator grant offers up to $60,000 per year for three years.

Targeting Glutamine Metabolism in MYC Driven Atypical Teratoid Rhabdoid Tumors

Project Updated (August 2019)

ALSF funded researcher Dr. Jeffrey Rubens discusses his groundbreaking research in atypical teratoid rhaboid tumors (AT/RT or ATRT) and shares tips for a successful Million Mile team. Watch below.

Background

Principal Investigator Name:

Jeffrey Rubens, MD

Project Title:

Targeting Glutamine Metabolism in MYC Driven Atypical Teratoid Rhabdoid Tumors

Year Awarded:

2017

Cancer Research Category:

Atypical Teratoid/Rhabdoid Tumor (AT/RT)

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

The Johns Hopkins University School of Medicine

Anthracycline-Induced Cardiac Toxicity in Pediatric Acute Myeloid Leukemia

Background

Principal Investigator Name:

Kelly Getz, PhD

Project Title:

Anthracycline-Induced Cardiac Toxicity in Pediatric Acute Myeloid Leukemia

Year Awarded:

2017

Cancer Research Category:

Acute Myeloid Leukemia (AML)

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

University of Pennsylvania

Epigenomic Mechanisms of Neuroblastoma Tumorigenesis

Background

Principal Investigator Name:

Jo Lynne Harenza, PhD

Project Title:

Epigenomic Mechanisms of Neuroblastoma Tumorigenesis

Year Awarded:

2017

Cancer Research Category:

Neuroblastoma

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

Children’s Hospital of Philadelphia

The Children's Hospital of Philadelphia

Background

Principal Investigator Name:

Andrea Flynn, MD

Project Title:

Targeting Protein Translation to Antagonize MYC-driven Neuroblastoma

Year Awarded:

2017

Cancer Research Category:

Neuroblastoma

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

Children’s Hospital of Philadelphia

New York University School of Medicine

Background

Acute lymphoblastic leukemia (ALL) is a form of cancer of the white blood cells, caused by the overproduction and accumulation of cancerous cells known as lymphoblasts. These lymphoblasts can arise from two different cell types known as T or B cells (designated as T-ALL or B-ALL). Both comprise the most common cancer among children and is the most frequent cause of death from cancer before 20 years of age. T-ALL is a particularly aggressive cancer, with fewer options for novel treatment strategies.

Principal Investigator Name:

Karen Bride, MD/PhD

Project Title:

Preclinical Efficacy of Daratumumab in T Cell Acute Lymphoblastic Leukemia

Year Awarded:

2017

Cancer Research Category:

Acute Lymphoblastic Leukemia (ALL)

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

New York University School of Medicine

University of Alabama at Birmingham

Background

Principal Investigator Name:

Emily Johnston, MD

Project Title:

End-of-Life Care of Children with Cancer: Variation and Stakeholder Priorities

Year Awarded:

2017

Cancer Research Category:

General Pediatric Cancer

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

University of Alabama at Birmingham

New York University School of Medicine

Background

Principal Investigator Name:

Anastasia Tikhonova, PhD

Project Title:

Identification and Targeting of Microenvironmental Factors Controlling Pediatric Leukemia

Year Awarded:

2017

Cancer Research Category:

Leukemia

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

New York University School of Medicine

Identification and Characterization of Pathways Dysregulated by MMSET E1099K Mutation in Relapsed Pediatric Acute Lymphoblastic Leukemia and Their Role in Drug Resistance

Background

Principal Investigator Name:

Joanna Pierro, DO

Project Title:

Identification and Characterization of Pathways Dysregulated by MMSET E1099K Mutation in Relapsed Pediatric Acute Lymphoblastic Leukemia and Their Role in Drug Resistance

Year Awarded:

2017

Cancer Research Category:

Acute Lymphoblastic Leukemia (ALL)

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

New York University School of Medicine

New York University School of Medicine

Background

Principal Investigator Name:

Francesco Boccalatte, PhD

Project Title:

Elucidating the Role of N-Myc in a High-risk Pediatric T Cell Leukemia

Year Awarded:

2017

Cancer Research Category:

Acute Lymphoblastic Leukemia (ALL)

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

New York University School of Medicine

Cancer Susceptibility and Signaling Pathways in Low-Grade Brain Tumors

Background

Hereditary cases of benign brain tumors are rare but they are devastating to affected children. Furthermore, knowledge gained by studying hereditary tumors can then be applied to better understand and treat non-familial cases. Our group discovered that defects in the fibroblast growth factor (FGF) pathway are involved in the development of brain tumors causing epilepsy.

Project Goal:

Principal Investigator Name:

Bárbara Rivera, PhD

Project Title:

Cancer Susceptibility and Signaling Pathways in Low-Grade Brain Tumors

Year Awarded:

2017

Cancer Research Category:

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

Jewish General Hospital

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