Institution:
Research Institute at Nationwide Children's HospitalResearcher(s):
Mary Beth Ross, MD/PhDGrant Type:
Young Investigator GrantsYear Awarded:
2006Type of Childhood Cancer:
LeukemiaProject Description:
The aim of this project is to define the effects of blocking E2A-PBX1 expression in a leukemia cell line containing the E2A-PBX1 translocation. Specifically we propose to study the effects of E2A-PBX1siRNA on growth and viability (aim 1) and whole genome gene expression (aim 2). Lastly, genes identified as having altered expression by siRNA will be compared to the previously published expression profile of E2A-PBX1 containing leukemias (aim 3).
