Neuroblastoma is the most common extra-cranial solid childhood cancer, accounting for 15% of all cancer deaths in children. Targeted therapies hold promise to improve the outcome for children with high-risk neuroblastoma, however this issue remains challenging. Amplification of the MYCN oncogene occurs in half of high-risk patients.
Principal Investigator Name:
Colin Sperring
Project Title:
Establishment and Validation of an IPS-based Neuroblastoma Model
The Pediatric Health Information System (PHIS) is a database of daily billing records from various units from 46 free-standing pediatric hospitals in the US. Utilizing PHIS, I will use methods similar to those already developed by the Aplenc lab to expand existing cohorts of pediatric patients with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) to allow for important clinical questions in pediatric leukemia to be definitively addressed.
Project Goal
Principal Investigator Name:
Christy He
Project Title:
Assembling ALL and AML Cohorts to Analyze Center-Level Variations in Induction Mortality and Evaluate Treatment Strategies for Relapsed AML
Cautious but curious, Avani was a rule-following, organized, fun-loving, and big-hearted little girl. Sadly, Avani passed away at 11 years old from a burst brain tumor. It wasn't until months later that her parents learned it was DIPG, cancer.
