Young Investigator Grants

Young Investigator grants are designed to fill the critical need for startup funds for less experienced researchers to pursue promising research ideas. Eligible applicants may apply during their fellowship training or early in their research careers but must not have achieved an appointment higher than Instructor. These grants encourage and cultivate the best and brightest researchers of the future and lead to long-term research projects. The Young Investigator grant offers up to $60,000 per year for three years.

Dana-Farber Cancer Institute

Research in the News: Dana-Farber researchers uncover link between Down syndrome and ALL

Principal Investigator Name:

Andrew Lane, MD, PhD

Project Title:

Histone Modification and Hmgn1 Overexpression as Drivers of B-ALL with Polysomy 21

Year Awarded:

2013

Cancer Research Category:

Leukemia

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

Dana-Farber Cancer Institute

Files:

Lane, Andrew.Nature Genetics 2014.pdf

Mayo Clinic

Background

Principal Investigator Name:

Shizhen Zhu, MD, PhD

Project Title:

The Role of PTPRD as a Tumor Suppressor in Neuroblastoma Pathogenesis

Year Awarded:

2013

Cancer Research Category:

Neuroblastoma

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

Mayo Clinic

Dana-Farber Cancer Institute

Background

Principal Investigator Name:

Hao-Ru Hsu, PhD

Project Title:

The Role of Prmt1 in Osteosarcoma Initiation and Metastasis

Year Awarded:

2013

Cancer Research Category:

Osteosarcoma

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

Dana-Farber Cancer Institute

The Children's Hospital of Philadelphia

Dr. Schnepp has joined the Department of Pediatrics at Emory University and is a member of the Aflac Cancer and Blood Disorders Center in Atlanta, GA.

Principal Investigator Name:

Robert Schnepp, MD, PhD

Project Title:

Defining the Mechanism by which LIN28B acts as an Oncogene in Neuroblastoma

Year Awarded:

2013

Cancer Research Category:

Neuroblastoma

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

Children’s Hospital of Philadelphia

Files:

A LIN28B-RAN-AURKA Signaling Network Promotes Neuroblastoma Tumorigenesis_CANCER CELL 2015

Mayo Clinic Jacksonville

Background
Malignant glioma accounts for a significant amount of morbidity and mortality among children with brain tumors. However, there are still no curable therapies. The abnormally accelerated blood vessel formation is thought to be a key pathogenic event in malignant glioma.

Principal Investigator Name:

Takahisa Kanekiyo, MD, PhD

Project Title:

LRP1 and Angiogenesis in Pediatric Malignant Glioma

Year Awarded:

2013

Cancer Research Category:

Brain Tumors

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

Mayo Clinic Jacksonville

Massachusetts General Hospital

Background

Principal Investigator Name:

Jessica Blackburn, PhD

Project Title:

PRL3 as a Novel Therapeutic Target for Relapsed T-cell Acute Lymphoblastic Leukemia

Year Awarded:

2013

Cancer Research Category:

Leukemia

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

Massachusetts General Hospital

Files:

Blackburn et al Cancer Cell 2014.pdf

Baylor College of Medicine

Background
Metastatic disease is responsible for about 90% of all cancer related deaths. Metastasis is when a patient's cancer has spread throughout the body and is not just located in one single tissue or organ. For children afflicted with metastatic osteosarcoma, the most common bone tumor in the pediatric population, it often means a very aggressive cancer that is associated with an extremely poor outcome.

Principal Investigator Name:

Jason T. Yustein, MD, PhD

Project Title:

Dissecting and Targeting the Wnt Signaling Pathway in Metastatic Osteosarcoma

Year Awarded:

2013

Cancer Research Category:

Osteosarcoma

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

Baylor College of Medicine

Washington University

Background

Principal Investigator Name:

Laura Schuettpelz, MD, PhD

Project Title:

The Regulation of Hematopoietic Stem Cell Function by Granulocyte-Colony Stimulating Factor

Year Awarded:

2013

Cancer Research Category:

General Pediatric Cancer

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

Washington University

University of Pennsylvania

Background
Beckwith-Wiedemann Syndrome (BWS) is a childhood overgrowth and cancer predisposition disorder due to changes on chromosome 11. Genetic changes similar to those observed in BWS are widespread and have been reported in isolated breast, pancreatic, adrenal, liver, renal, prostate, and colon cancers.

Principal Investigator Name:

Jennifer Kalish, MD, PhD

Project Title:

Dissecting the Mechanism of Overgrowth and Tumorigenesis in Beckwith-Wiedemann Syndrome

Year Awarded:

2013

Cancer Research Category:

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

University of Pennsylvania

Files:

kalish.2013.jiangIJDB.pdf

kalish_pediatric_blood_and_cancer_2017.pdf

Memorial Sloan-Kettering Cancer Center

Background
Each year, hundreds of children undergo radiation therapy, in order to treat their primary cancer. Due to radiation's potency and in the absence of highly effective protection systems, these children may suffer brain damage and experience developmental problems. Also, radiation can affect their skin and bone marrow, causing skin cancer and leukemia.

Principal Investigator Name:

Charalambos Kaittanis, PhD

Project Title:

Multifunctional Nanomaterials for the Prevention of Radiotherapy's Side Effects and Childhood Cancers

Year Awarded:

2013

Cancer Research Category:

General Pediatric Cancer

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

Massachusetts General Hospital

Files:

kaittanis_plos_one_2017.pdf

kaitannis_nano_letters_full_text.pdf

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