Young Investigator Grants

Young Investigator grants are designed to fill the critical need for startup funds for less experienced researchers to pursue promising research ideas. Eligible applicants may apply during their fellowship training or early in their research careers but must not have achieved an appointment higher than Instructor. These grants encourage and cultivate the best and brightest researchers of the future and lead to long-term research projects. The Young Investigator grant offers up to $60,000 per year for three years.

Fred Hutchinson Cancer Research Center

Background

Principal Investigator Name:

Colin Godwin, MD

Project Title:

Novel Antibodies to the C2-set Domain of CD33 for Acute Myeloid Leukemia Immunotherapy

Year Awarded:

2018

Cancer Research Category:

Acute Myeloid Leukemia (AML)

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

Fred Hutchinson Cancer Research Center

Accessing Combinatorial Effect of PARP Inhibitor with DNA Damaging Agent in Rhabdomyosarcoma at Single Cell Resolution

Background: Combination therapies using cytotoxic drugs have revolutionized the treatment of pediatric rhabdomyosarcoma (RMS). However, cure rates have largely remained stagnant since their implementation. We have recently generated an optically-clear, immune-deficient zebrafish that can engraft human RMS tumors, with growth kinetics and histological features similar to those grown in immune-deficient murine models.

Principal Investigator Name:

Chuan Yan, PhD

Project Title:

Accessing Combinatorial Effect of PARP Inhibitor with DNA Damaging Agent in Rhabdomyosarcoma at Single Cell Resolution

Year Awarded:

2018

Cancer Research Category:

Rhabdomyosarcoma

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

Massachusetts General Hospital

Cooperating Signaling Networks Regulate Cell Survival of Pediatric Ph-like ALL

B cell acute lymphoblastic leukemia (B-ALL) is the most common cancer in children. Despite significant improvements in chemotherapy combinations, approximately 20% of children with high-risk B-ALL will fail their treatments. It is now clear that there are different subtypes of ALL with different genetic mutations. These mutations activate and disrupt pathways within the leukemia cells that allows the cells to grow out of control.

Principal Investigator Name:

Christian Hurtz, PhD

Project Title:

Cooperating Signaling Networks Regulate Cell Survival of Pediatric Ph-like ALL

Year Awarded:

2018

Cancer Research Category:

Acute Lymphoblastic Leukemia (ALL)

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

University of Pennsylvania

Beyond Febrile Neutropenia: Risks Associated with Antibiotic Choice in Children with Leukemia that Undergo Transplant

Background: A subset of children with high-risk leukemia require stem cell transplant in order to cure their disease. Due to the profound immunosuppression associated with this procedure, children undergoing transplant receive a substantial number of antibiotics. However, the implications of such extensive antibiotic exposures are not well understood.

Principal Investigator Name:

Caitlin Elgarten, MD

Project Title:

Beyond Febrile Neutropenia: Risks Associated with Antibiotic Choice in Children with Leukemia that Undergo Transplant

Year Awarded:

2018

Cancer Research Category:

Leukemia

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

Children’s Hospital of Philadelphia

Pedi-PRESTO: Pediatric Patient-Reported Symptom Tracking in Oncology

Background: More than 40,000 children undergo cancer treatment in the U.S. annually and all patients experience symptoms and side effects from their therapy. These can range in severity from minor to life-threatening and cause significant distress and suffering. The use of patient-reported outcomes, which are standardized reports of a patient's health condition directly from the patient or caregiver, can make patients and their parents feel more in control of their well-being and help their doctors to control their symptoms.

Principal Investigator Name:

Allison Barz Leahy, MD

Project Title:

Pedi-PRESTO: Pediatric Patient-Reported Symptom Tracking in Oncology

Year Awarded:

2018

Cancer Research Category:

General Pediatric Cancer

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

Children’s Hospital of Philadelphia

Interrogation of Neuroblastoma Dependencies and RNAs on the Core-Regulatory Circuitry for Therapeutic Inhibition

Background
Neuroblastoma (NB) is one of the most common solid tumors of childhood. Despite multimodality therapy, nearly half of patients with high-risk neuroblastoma will die of this disease. High-risk neuroblastoma typically has many DNA copies of the MYCN gene. I recently identified a group of six proteins which work together to form a network to drive neuroblastoma. Disrupting any one of these proteins causes all to be lost and the tumor cells to die. Unfortunately, there is no known way to target MYCN or these other proteins right now.

Principal Investigator Name:

Adam Durbin, PhD

Project Title:

Interrogation of Neuroblastoma Dependencies and RNAs on the Core-Regulatory Circuitry for Therapeutic Inhibition

Year Awarded:

2018

Cancer Research Category:

Neuroblastoma

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

St. Jude Children’s Research Hospital

Development and Characterization of Novel Models of Human Osteosarcoma Development and Metastasis

Background

Principal Investigator Name:

Beau Webber, PhD

Project Title:

Development and Characterization of Novel Models of Human Osteosarcoma Development and Metastasis

Year Awarded:

2017

Cancer Research Category:

Osteosarcoma

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

University of Minnesota

University of Chicago

Background

Principal Investigator Name:

Sakshi Uppal, PhD

Project Title:

The Impact of Hypoxia on Epigenetic Changes in Neuroblastoma

Year Awarded:

2017

Cancer Research Category:

Neuroblastoma

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

University of Chicago

University of California San Francisco

Background

Principal Investigator Name:

Anica Wandler, PhD

Project Title:

Overcoming Glucocorticoid Resistance in Lymphoid Cancers

Year Awarded:

2017

Cancer Research Category:

Acute Lymphoblastic Leukemia (ALL)

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

University of California San Francisco

High-Throughput Gene-Editing via Microfluidic Cell Deformability to Enable Off-the-Shelf Allogeneic Cellular Immunotherapies

Background

Principal Investigator Name:

Steven Jonas, MD/PhD

Project Title:

High-Throughput Gene-Editing via Microfluidic Cell Deformability to Enable Off-the-Shelf Allogeneic Cellular Immunotherapies

Year Awarded:

2017

Cancer Research Category:

Leukemia

Category of Grant:

Young Investigator Grants

Medical, Nurse Researcher, Quality of LIfe:

Medical

Institution:

University of California, Los Angeles

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