Dr. Trevor Pugh is part of the Crazy 8 team studying a vaccine for childhood cancer predisposition syndromes.

In 2019, Dr. Pugh received a Single-cell Pediatric Cancer Atlas Grant from Alex's Lemonade Stand Foundation for his research in Dissecting Pediatric Brain Tumour Progression Using Single-nuclei Sequencing. Dr. Pugh is a cancer genomics researcher and a board-certified molecular geneticist. His landmark cancer genome studies focus on three pediatric solid tumours: medulloblastoma, neuroblastoma, and pleuropulmonary blastoma.

His research program seeks to understand the clinical implications of clonal shifts in cancer and non-cancerous cell populations in tumours during treatment, most recently using cell-free DNA sequencing, single cell RNA-seq analysis, and immune repertoire profiling. He and his collaborators develop software tools and data analysis systems required to enable collaborative, clinically-oriented genome research.