Overcoming Menin-inhibitor resistance

Institution: 

Children’s Hospital of Philadelphia

Researcher(s): 

Kathrin Bernt, MD

Grant Type: 

Reach Grants

Year Awarded: 

2024

Type of Childhood Cancer: 

Acute Lymphoblastic Leukemia (ALL)

Menin inhibitors are a new class of drugs that has shown great promise for the treatment of certain highly aggressive leukemias in children. However, there are many patients in whom the drug does not work. We have developed a strategy of combining Menin inhibitors with a second class of drugs called LSD1 inhibitors to improve efficacy and overcome resistance.

Project Goal: 

In this project, we will test our new strategy on a panel of patient samples for th subtypes of leukemia that this combination is designed to work on. If we find that this combination is broadly effective, then this data will serve as the basis for a clinical trial.