The Interplay Between Histone Mutations and Replication Stress in Shaping Glioma Phenotypes
Institution:
Dana-Farber Cancer InstituteResearcher(s):
Pratiti Bandopadhayay, PhDGrant Type:
'A' Award GrantsYear Awarded:
2021Type of Childhood Cancer:
GliomaProject Description:
Pediatric high-grade gliomas are a lethal disease of childhood with a lack of curative treatments. They have been found to be caused by mutations in a group of proteins called histones, which help cells regulate which genes are turned on or off at any one time. This project seeks to understand how histone mutations help pediatric high-grade gliomas grow, with the hope that our findings will help with the development of novel approaches to treat these devastating tumors.
Project Goals:
The goal of this project is to understand how histone mutations interact with other proteins in cells which help turn normal cells into cancer cells. We hope to understand this so that we can develop new treatments to reverse these changes.
