ALSF Childhood Cancer Research Grants
With your support, we have been able to fund outstanding research, leading toward cures and improved quality of life for children with cancer. Browse through more than 1,500 funded projects below.
Use the search tool to refine your results. You can also click on a heading to sort by project title, institution name, or year the grant was awarded. Click on the project title to read more information.
You can learn about ALSF's grant review process here.
ALSF Funded Research Projects
Project Title | Institution / Principal Investigator(s) | Grant Type | Year | State |
---|---|---|---|---|
Utilizing chromatin directed inhibitors to regulate gene expression in Ewing sarcoma for therapeutic benefit | University of North Carolina / Justin Sperlazza, MD/PhD | Young Investigator Grants | 2024 | North Carolina |
Modifying CAR T cell epigenetic programs to improve therapy against aggressive pediatric brain tumors | St. Jude Children’s Research Hospital / Meghan Ward, PhD | Young Investigator Grants | 2024 | Tennessee |
Activation of Anti-Leukemia Immunity by Targeting Protein Arginine Methyltransferase | City of Hope National Medical Center / Ling Li, PhD | R Accelerated Award Grants | 2023 | California |
Empowering specificity of AML immunotherapies by HSC engineering | Aflac Cancer Center and Blood Disorders Service of Children’s Healthcare of Atlanta / Pietro Genovese | Catalyst Grants | 2023 | Georgia |
Empowering specificity of AML immunotherapies by HSC engineering | Boston Children’s Hospital / Pietro Genovese | Catalyst Grants | 2023 | Massachusetts |
Circumventing Pediatric Solid Tumor Microenvironment Resistance by Combinatorial CAR NK and Immunomodulating Therapy | New York Medical College / Mitchell Cairo, MD | Reach Grants | 2023 | New York |
Reversing Feedback Immunosuppression during Oncolytic Virotherapy of Pediatric High Grade Glioma | Augusta University Research Institute, Inc. / Bangxing Hong, PhD | Reach Grants | 2023 | Georgia |
Synthetic Gene Expression Regulatory Switches (SynGERS) for Improved CAR T Cell Function in Pediatric Solid Tumors | Baylor College of Medicine / Leidy Diana Caraballo Galva, PhD | Young Investigator Grants | 2023 | Texas |
A Novel Adjunctive LAT-Activating CART (ALA-CART) Cell Platform for the Treatment of Acute Leukemia | University of Colorado Denver_ Anschutz Medical Campus / Catherine Danis, PhD | Young Investigator Grants | 2023 | Colorado |
Phase I trial of multilamellar mRNA lipid particles for recurrent pediatric high grade glioma | University of Florida / Elias Sayour, MD/PhD | R Accelerated Award Grants | 2022 | Florida |
Exploiting glypican diversity in neuroblastoma plasticity with bicistronic CAR T cell targeting | Children’s Hospital of Philadelphia / Kristopher Bosse, MD | 'A' Award Grants | 2022 | Pennsylvania |
Epigenetic Enhancement of MHCI to Augment Neuroblastoma Immunotherapy | University of Wisconsin - Madison / Paul Sondel, MD, PhD and Amy Erbe-Gurel, PhD | Innovation Grants | 2022 | Wisconsin |
Isoform-specific TNC-redirected T cell Therapy for DIPG | St. Jude Children’s Research Hospital / Stephen Gottschalk, MD and Giedre Krenciute, PhD | Innovation Grants | 2022 | Tennessee |
GD2-directed CAR T cell therapy for H3K27M+ spinal cord diffuse midline glioma | Board of Trustees of the Leland Stanford Junior University / Michelle Monje | Catalyst Grants | 2021 | California |
Activating Metabolic Pathways to Increase the Persistence of Leukemia Targeting T Cells | Children’s Hospital of Pittsburgh / Erica Braverman, MD | Young Investigator Grants | 2021 | Pennsylvania |
Dual PTK7/GD2 Gamma Delta CAR T Cell Therapy for Neuroblastoma | Emory University / Kelly Goldsmith, MD & H. Trent Spencer, PhD & Chris B. Doering, PhD | Reach Grants | 2021 | Georgia |
In-vivo characterization of MYCN-driven immunosuppression | University of California San Francisco / William Weiss, MD/PhD | Innovation Grants | 2021 | California |
High-throughput CAR NKT Library Screen for Improving Neuroblastoma Immunotherapy | Baylor College of Medicine / Xavier Rios, MD/PhD | Young Investigator Grants | 2020 | Texas |
GPC2 CAR T Cell Targeted Delivery of BiKEs in High-Risk Neuroblastoma | Children’s Hospital of Philadelphia / Guillem Pascual-Pasto, PhD | Young Investigator Grants | 2020 | Pennsylvania |
Synergistic Activity of Anti-GD2 Antibody and CD47-Blockade for Immunotherapy of Neuroblastoma and Osteosarcoma | The Board of Trustees of the Leland Stanford Junior University / Robbie Majzner, MD | 'A' Award Grants | 2019 | California |
Elucidating the Role of SETD2 in Pediatric High Grade Glioma Formation | Children’s Hospital of Philadelphia / Thomas De Raedt, PhD | 'A' Award Grants | 2019 | Pennsylvania |
The use of hematopoietic stem and progenitor cells to reverse treatment resistance to PD-1 blockade | University of Florida / Catherine Flores, PhD | Innovation Grants | 2019 | Florida |
Predicting and Overcoming Resistance to Immunotherapy in Pediatric High-Grade Glioma | Ann & Robert H. Lurie Children’s Hospital of Chicago / Oren Becher, MD & Robert Wechsler-Reya, PhD | Innovation Grants | 2019 | Illinois |
ECM-targeted CAR T-cell therapy for high-grade glioma | St. Jude Children’s Research Hospital / Jessica Wagner, PhD | Young Investigator Grants | 2019 | Tennessee |
Targeted Hyperactivation of PI3K/AKT in B-cell malignancies | Dana-Farber Cancer Institute / Vishal Khairnar, PhD | Young Investigator Grants | 2019 | Massachusetts |
Improving CAR T-Cell Therapy for Pediatric Osteosarcoma by Manipulating Arginine Metabolism | St. Jude Children’s Research Hospital / Shannon Lange, PhD | Young Investigator Grants | 2019 | Tennessee |
Identification of Synthetically Immunogenic Compounds to Synergize with Immunotherapy in Neuroblastoma | Children’s Hospital of Philadelphia / Adam Wolpaw, MD/PhD | Young Investigator Grants | 2019 | Pennsylvania |
Multiplex Ion Beam Imaging of Pediatric Cancers | Stanford University School of Medicine / Crystal L. Mackall, MD | Crazy 8 Pilots | 2019 | California |
Immuno-therapeutic Targeting of CD56 in CBA2T3/GLIS2-AML in Children | Fred Hutchinson Cancer Research Center / Soheil Meshinchi, MD/PhD | Reach Grants | 2018 | Washington |
Augmenting Chimeric Antigen Receptor T Cell Induced Epitope Spreading for Pediatric Solid Tumors | Children’s Hospital of Philadelphia / Michael Leibowitz, MD/PhD | Young Investigator Grants | 2018 | Pennsylvania |
Novel Antibodies to the C2-set Domain of CD33 for Acute Myeloid Leukemia Immunotherapy | Fred Hutchinson Cancer Research Center / Colin Godwin, MD | Young Investigator Grants | 2018 | Washington |
Natural Killer T cells with an IL-15-armored GD2-specific CAR for Children with Neuroblastoma | Baylor College of Medicine / Andras Heczey, MD | Bio-Therapeutic Impact Award | 2017 | Texas |
Long Non-Coding RNAs as Novel Biomarkers and Therapeutic Targets in Pediatric Leukemia | New York University School of Medicine / Iannis Aifantis, PhD | Innovation Grants | 2017 | New York |
Preclinical Efficacy of Daratumumab in T Cell Acute Lymphoblastic Leukemia | New York University School of Medicine / Karen Bride, MD/PhD | Young Investigator Grants | 2017 | New York |
Development of Novel Biomarkers for Immunotherapy in Neuroblastoma | Columbia Institute for Cancer Genetics / Shuobo Boboila, PhD | Young Investigator Grants | 2017 | New York |
Engineering the CAR T Cells to Overcome Tumor Derived Immune-Inhibition in Glioblastoma | Baylor College of Medicine / Meenakshi Hegde, MD | 'A' Award Grants | 2016 | Texas |
An Engineered Nanoimmunotherapy for Treating Neuroblastoma | George Washington University / Rohan Fernandes, PhD | 'A' Award Grants | 2016 | District of Columbia |
DFMO Synergy with Chemo-immunotherapy to Eradicate MYC-Driven Neuroblastoma | Children’s Hospital of Philadelphia / Michael Hogarty, MD | Reach Grants | 2016 | Pennsylvania |
Enhancing Pediatric Sarcoma Immunotherapy by Drug Induced Expression of Tumor-Specific Cryptic Neoantigens | University of Minnesota / David Largaespada, PhD | Innovation Grants | 2016 | Minnesota |
Enhancing Immunotherapy of Neuroblastoma | The Regents of the University of California, San Diego / Alice Yu, MD/PhD & Mitchell Diccianni, PhD | Innovation Grants | 2016 | California |
Role of Kindlin-3 In Natural Killer Cell Mediated Tumor Killing | Children’s Hospital of Wisconsin - Milwaukee / Nathan Schloemer, MD | Young Investigator Grants | 2016 | Wisconsin |
Genetically Engineered T Cells as Therapy for Pediatric Glioma | Baylor College of Medicine / Giedre Krenciute, PhD | Young Investigator Grants | 2016 | Texas |
GPC2 as an Oncogene and Immunotherapeutic Target in High-risk Neuroblastoma | Children’s Hospital of Philadelphia / Kristopher Bosse, MD | Young Investigator Grants | 2016 | Pennsylvania |
Developing Targeted Immunotherapy Against Pediatric Acute Myeloid Leukemia | Fred Hutchinson Cancer Research Center / Melinda Biernacki, MD | Young Investigator Grants | 2016 | Washington |
CD19 Delta Ex2 Isoform as a Target for Alternative Therapies in Relapsed Pediatric B-ALL | Children’s Hospital of Philadelphia / Asen Bagashev, PhD | Young Investigator Grants | 2016 | Pennsylvania |
Adoptive Immunotherapy of Tr1 Cells to Improve Outcome of Allo-HSCT Treatment for Pediatric AML | Stanford University / Maria-Grazia Roncarolo, MD & Rosa Bachetta, MD | Reach Grants | 2015 | California |
Inside-Out Immunotherapy: Combating Neuroblastoma via Nanoparticle-Directed Reprogramming of the Tumor Microenvironment | Vanderbilt University Medical Center / John Wilson, PhD | 'A' Award Grants | 2015 | Tennessee |
Genetically Modified, Cord Blood Derived Natural Killer Cell Therapy for High Grade Pediatric Brain Tumors | Children’s Research Institute / Conrad Russell Cruz, MD, PhD | 'A' Award Grants | 2015 | District of Columbia |
Expanding Innovative Pediatric Cancer Clinical Trial Access at Stanford | Stanford University / Maria-Grazia Roncarolo, M.D. & Sherri Spunt, M.D. | Phase I/II Infrastructure Grants | 2015 | California |
Building Capacity for the Clinical Trials Office at Children's Hospital of Wisconsin - Strengthening Phase I & II Trials Infrastructure | Children’s Hospital of Wisconsin - Milwaukee / Michael J. Burke, MD | Phase I/II Infrastructure Grants | 2015 | Wisconsin |
Integrative Genomic and Immunogenomic Analysis of Neuroblastoma | University of California at Santa Cruz / David Haussler, PhD | Innovation Grants | 2015 | California |
Identifying how Pre-existing Anti-Therapeutic Antibodies (PATA) are Associated with Better Outcome in a Clinical Trial of ADCC-inducing Anti-GD2 mAb | University of Wisconsin - Madison / Paul Sondel, MD, PhD | Innovation Grants | 2015 | Wisconsin |
Antibody Targeted Natural Killer Cell-Derived Extracellular Vesicles for the Treatment of Childhood Acute Lymphoblastic Leukemia and Neuroblastoma | Children’s Hospital Los Angeles / Robert Seeger, MD & Alan Wayne, MD | Innovation Grants | 2015 | California |
Enhancing Effectiveness of Immune Checkpoint Therapy in Neuroblastoma | Children’s Hospital Los Angeles / Shahab Asgharzadeh, MD | Innovation Grants | 2015 | California |
CAMKV as a Target for Immunotherapy in MYCN-Amplified Neuroblastoma | Children’s Hospital of Philadelphia / Robyn Sussman, PhD | Young Investigator Grants | 2015 | Pennsylvania |
Novel Role of Hematopoietic Stem Cells in Immunologic Rejection of Malignant Pediatric Brain Tumors | University of Florida / Catherine Flores, PhD | Young Investigator Grants | 2015 | Florida |
Immunotherapy of Neuroblastoma with CAR.GD2 NKT Cells | Baylor College of Medicine / Leonid S. Metelitsa, M.D., Ph.D. | Bio-Therapeutic Impact Award | 2014 | Texas |
Phase I Trial of Indoximod in Combination with Temozolomide-based Therapy for Children with Progressive Primary Brain Tumors | Georgia Health Sciences University Research Institute, Inc. / Theodore Johnson, M.D., Ph.D. | Bio-Therapeutic Impact Award | 2014 | Georgia |
HA-1 TCR T-cell Immunotherapy for Acute Leukemia | Fred Hutchinson Cancer Research Center / Marie Bleakley, M.D., Ph.D. | Bio-Therapeutic Impact Award | 2014 | Washington |
Identifying Novel Therapeutic Combinations with 131I-MIBG to Treat Relapsed and Refractory Neuroblastoma | The Regents of the University of California San Francisco / William Clay Gustafson, M.D., Ph.D. | Reach Grants | 2014 | California |
Two-pronged Cell Therapy: Engineering T Cells to Redirect Bystander T- and NK-Cells to Pediatric Cancer | Baylor College of Medicine / Stephen Gottschalk, M.D. | Innovation Grants | 2014 | Texas |
Converting the Glioblastoma Multiforme Tumor-Associated Macrophage Phenotype | The Johns Hopkins University School of Medicine / Alan D. Friedman, M.D. | Innovation Grants | 2014 | Maryland |
A Developmental Model to Characterize the Epigenetic Origins of the Retinoblastoma Tumor Initiating Cell | The Johns Hopkins University School of Medicine / Jeffrey Huo, MD, PhD | Young Investigator Grants | 2014 | Maryland |
Immunotherapy Of Neuroblastoma With Natural Killer T Cells Engineered To Target O-acetyl-GD2 | Baylor College of Medicine / Andras Heczey, MD | Young Investigator Grants | 2014 | Texas |
Immunotherapy for Pediatric Atypical Teratoid/Rhabdoid Tumor | Baylor College of Medicine / William Decker, PhD | Reach Grants | 2013 | Texas |
Accelerating Access to Cellular Therapies for the Treatment of Childhood Malignancies | Seattle Children’s Hospital and Regional Medical Center / Julie Park, MD | Phase I/II Infrastructure Grants | 2013 | Washington |
Engager T cells for the Adoptive Immunotherapy of Pediatric Malignancies | Baylor College of Medicine / Stephen Gottschalk, MD | Innovation Grants | 2013 | Texas |
Multispecific T Cells for Adoptive Immunotherapy of Pediatric High Grade Glioma (HGG) | Baylor College of Medicine / Nabil Ahmed, MD, MSc | Innovation Grants | 2013 | Texas |
Pre-Clinical Testing of T cells Coded with CARs for DIPG | University of Texas / Laurence Cooper, MD, PhD | Innovation Grants | 2013 | Texas |
Alex's Lemonade Stand Foundation Center of Excellence in Childhood Cancer Drug Development and Clinical Pharmacology at The Children's Hospital of Philadelphia | Children’s Hospital of Philadelphia / Frank Balis, MD - Scholar: Emily Blauel, MD | Center of Excellence Grants | 2013 | Pennsylvania |
Epigenetic Regulation of T cell Activation and Immunotherapy | The Johns Hopkins University School of Medicine / Brian Ladle, MD, PhD | Young Investigator Grants | 2013 | Maryland |
Multifunctional Nanomaterials for the Prevention of Radiotherapy's Side Effects and Childhood Cancers | Massachusetts General Hospital / Charalambos Kaittanis, PhD | Young Investigator Grants | 2013 | Massachusetts |
IDO-based Immunotherapy for Pediatric Brain Tumors | Georgia Health Sciences University Research Institute, Inc. / Theodore Johnson, MD, PhD | 'A' Award Grants | 2013 | Georgia |
Engineering the Lymph Node Environment with Therapeutic Vaccine Depots to Combat Neuroblastoma | University of Maryland, College Park / Christopher Jewell, PhD | 'A' Award Grants | 2013 | Maryland |
Molecular Signature of Inflammation | Medical College of Wisconsin / Subramaniam Malarkannan, PhD | Springboard Grants | 2013 | Wisconsin |
Adoptive Cell Therapy Targeting Antigen Escape Variants in Childhood High Grade Glioma | Baylor College of Medicine / Meenakshi Hegde | Young Investigator Grants | 2012 | Texas |
V alpha-invariant NKT cells as a novel platform for cancer immunotherapy | Baylor College of Medicine / Leonid Metelitsa, MD, PhD | Innovation Grants | 2012 | Texas |
Developing Immune-modulatory Strategies Against Primary and Metastatic Tumors in the Central Nervous System | Case Western Reserve University / Alex Huang, MD, PhD | Innovation Grants | 2012 | Ohio |
Predicting Outcome and Ameliorating Toxicities of the Immunotherapy of Neuroblastoma | University of California, San Diego / Alice Yu, MD, PhD | Innovation Grants | 2011 | California |
Exploring a novel immunotherapy: cooperation of endogenous CD8+ t-cells and exogenous, allogeneic CD4+ t-cells. | The Johns Hopkins University School of Medicine / Heather Symons | Young Investigator Grants | 2009 | Maryland |
Reciprocal interactions between tumor killer dendritic cells and tumor-induced regulatory T lymphocytes | University of Arizona / Nicolas Larmonier, PhD | Young Investigator Grants | 2008 | Arizona |
Adoptive immunotherapy using clinical-grade T cells. | University of Texas M.D. Anderson Cancer Center / Laurence Cooper, MD, PhD | Innovation Grants | 2007 | Texas |
Immunotherapy for Osteosarcoma and Ewing sarcoma | Baylor College of Medicine / Nabil Ahmed, MD, MSc | Young Investigator Grants | 2007 | Texas |