ALSF Childhood Cancer Research Grants
With your support, we have been able to fund outstanding research, leading toward cures and improved quality of life for children with cancer. Browse through more than 1,500 funded projects below.
Use the search tool to refine your results. You can also click on a heading to sort by project title, institution name, or year the grant was awarded. Click on the project title to read more information.
You can learn about ALSF's grant review process here.
ALSF Funded Research Projects
Project Title | Institution / Principal Investigator(s) | Grant Type | Year | State |
---|---|---|---|---|
Improving homing and activity of CAR T cells in pediatric sarcomas | University of Colorado Denver / Joselyn Cruz Cruz, PhD | Young Investigator Grants | 2024 | Colorado |
Vaccine-boosted CAR T cell therapy for high risk neuroblastoma | Children’s Hospital of Philadelphia / Timothy Spear, MD/PhD | Young Investigator Grants | 2024 | Pennsylvania |
Modifying CAR T cell epigenetic programs to improve therapy against aggressive pediatric brain tumors | St. Jude Children’s Research Hospital / Meghan Ward, PhD | Young Investigator Grants | 2024 | Tennessee |
Synthetic gene expression regulator switches (SynGERS) expressed in CAR T cells to cure children with solid tumors | Baylor College of Medicine / Andras Heczey, MD | R Accelerated Award Grants | 2023 | Texas |
Empowering specificity of AML immunotherapies by HSC engineering | Aflac Cancer Center and Blood Disorders Service of Children’s Healthcare of Atlanta / Pietro Genovese | Catalyst Grants | 2023 | Georgia |
Empowering specificity of AML immunotherapies by HSC engineering | Boston Children’s Hospital / Pietro Genovese | Catalyst Grants | 2023 | Massachusetts |
Synthetic Gene Expression Regulatory Switches (SynGERS) for Improved CAR T Cell Function in Pediatric Solid Tumors | Baylor College of Medicine / Leidy Diana Caraballo Galva, PhD | Young Investigator Grants | 2023 | Texas |
A Novel Adjunctive LAT-Activating CART (ALA-CART) Cell Platform for the Treatment of Acute Leukemia | University of Colorado Denver_ Anschutz Medical Campus / Catherine Danis, PhD | Young Investigator Grants | 2023 | Colorado |
Exploiting glypican diversity in neuroblastoma plasticity with bicistronic CAR T cell targeting | Children’s Hospital of Philadelphia / Kristopher Bosse, MD | 'A' Award Grants | 2022 | Pennsylvania |
Targeted nanoparticle-mediated “cold”-to-“hot” reprogramming of the tumor microenvironment of high-risk neuroblastoma | University of Massachusetts Chan Medical School / Prabhani Atukorale, PhD & Jason Shohet, MD, PhD | Innovation Grants | 2022 | Massachusetts |
Targeted nanoparticle-mediated “cold”-to-“hot” reprogramming of the tumor microenvironment of high-risk neuroblastoma | University of Massachusetts Amherst / Prabhani Atukorale, PhD & Jason Shohet, MD, PhD | Innovation Grants | 2022 | Massachusetts |
Isoform-specific TNC-redirected T cell Therapy for DIPG | St. Jude Children’s Research Hospital / Stephen Gottschalk, MD and Giedre Krenciute, PhD | Innovation Grants | 2022 | Tennessee |
GD2-directed CAR T cell therapy for H3K27M+ spinal cord diffuse midline glioma | Board of Trustees of the Leland Stanford Junior University / Michelle Monje | Catalyst Grants | 2021 | California |
Investigating Epigenetic Mechanisms of Response to Allogenic CAR T Cell Therapy | St. Jude Children’s Research Hospital / Caitlin Zebley, MD/PhD | Young Investigator Grants | 2021 | Tennessee |
Dual PTK7/GD2 Gamma Delta CAR T Cell Therapy for Neuroblastoma | Emory University / Kelly Goldsmith, MD & H. Trent Spencer, PhD & Chris B. Doering, PhD | Reach Grants | 2021 | Georgia |
GPC2 CAR T Cell Targeted Delivery of BiKEs in High-Risk Neuroblastoma | Children’s Hospital of Philadelphia / Guillem Pascual-Pasto, PhD | Young Investigator Grants | 2020 | Pennsylvania |
Optimizing TCRαβ+/CD19+-depleted haploidentical HSCT for ALL using donor-derived genome-edited CAR T cells | Stanford University School of Medicine / Alice Bertaina, MD/PhD | Reach Grants | 2019 | California |
Generation of CMV-specific CD19 CAR T cells Using Cytokine Capture Followed by Lentiviral Transduction and Expansion | Research Institute at Nationwide Children's Hospital / Margaret Lamb, MD | Reach Grants | 2019 | Ohio |
ECM-targeted CAR T-cell therapy for high-grade glioma | St. Jude Children’s Research Hospital / Jessica Wagner, PhD | Young Investigator Grants | 2019 | Tennessee |
Targeted Hyperactivation of PI3K/AKT in B-cell malignancies | Dana-Farber Cancer Institute / Vishal Khairnar, PhD | Young Investigator Grants | 2019 | Massachusetts |
Improving CAR T-Cell Therapy for Pediatric Osteosarcoma by Manipulating Arginine Metabolism | St. Jude Children’s Research Hospital / Shannon Lange, PhD | Young Investigator Grants | 2019 | Tennessee |
Enhancing the therapeutic efficacy of chimeric antigen receptor T cells for acute myeloid leukemia | Washington University / Miriam Kim, MD | Young Investigator Grants | 2019 | Missouri |
Kidney Disease after CD19-Targeted Chimeric Antigen Receptor T Cell Therapy for Pediatric Acute Lymphoblastic Leukemia | Children’s Hospital of Philadelphia / Regina Myers, MD | Young Investigator Grants | 2019 | Pennsylvania |
Targeting Chondroitin Sulphate Proteoglycan 4 (CSPG4) in Glioblastoma | University of North Carolina / Gianpietro Dotti, MD & Barbara Savoldo, MD/PhD | Reach Grants | 2017 | North Carolina |
Natural Killer T cells with an IL-15-armored GD2-specific CAR for Children with Neuroblastoma | Baylor College of Medicine / Andras Heczey, MD | Bio-Therapeutic Impact Award | 2017 | Texas |
Engineering the CAR T Cells to Overcome Tumor Derived Immune-Inhibition in Glioblastoma | Baylor College of Medicine / Meenakshi Hegde, MD | 'A' Award Grants | 2016 | Texas |
An Engineered Nanoimmunotherapy for Treating Neuroblastoma | George Washington University / Rohan Fernandes, PhD | 'A' Award Grants | 2016 | District of Columbia |
Preclinical Testing of Candidate Therapeutics in a Pediatric Spinal Cord High-grade Glioma Model | Stanford University / Michelle Monje, MD/PhD | Innovation Grants | 2016 | California |
GPC2 as an Oncogene and Immunotherapeutic Target in High-risk Neuroblastoma | Children’s Hospital of Philadelphia / Kristopher Bosse, MD | Young Investigator Grants | 2016 | Pennsylvania |
Immunotherapy of Neuroblastoma with CAR.GD2 NKT Cells | Baylor College of Medicine / Leonid S. Metelitsa, M.D., Ph.D. | Bio-Therapeutic Impact Award | 2014 | Texas |
Immunotherapy Of Neuroblastoma With Natural Killer T Cells Engineered To Target O-acetyl-GD2 | Baylor College of Medicine / Andras Heczey, MD | Young Investigator Grants | 2014 | Texas |
Pre-Clinical Testing of T cells Coded with CARs for DIPG | University of Texas / Laurence Cooper, MD, PhD | Innovation Grants | 2013 | Texas |
Molecular Signature of Inflammation | Medical College of Wisconsin / Subramaniam Malarkannan, PhD | Springboard Grants | 2013 | Wisconsin |
Texas Children's Cancer Center Alex's Lemonade Stand Center of Excellence | Baylor College of Medicine / Stacey Berg, MD - Scholars: Holly Lindsay, MD/MS, Sarah Injac, MD | Center of Excellence Grants | 2012 | Texas |
V alpha-invariant NKT cells as a novel platform for cancer immunotherapy | Baylor College of Medicine / Leonid Metelitsa, MD, PhD | Innovation Grants | 2012 | Texas |