ALSF Childhood Cancer Research Grants
With your support, we have been able to fund outstanding research, leading toward cures and improved quality of life for children with cancer. Browse through more than 1,500 funded projects below.
Use the search tool to refine your results. You can also click on a heading to sort by project title, institution name, or year the grant was awarded. Click on the project title to read more information.
You can learn about ALSF's grant review process here.
ALSF Funded Research Projects
Project Title | Institution / Principal Investigator(s) | Grant Type | Year | State |
---|---|---|---|---|
Utilizing chromatin directed inhibitors to regulate gene expression in Ewing sarcoma for therapeutic benefit | University of North Carolina / Justin Sperlazza, MD/PhD | Young Investigator Grants | 2024 | North Carolina |
MYCN-induced molecular clock disruption and metabolic rewiring drive neuroblastoma | Baylor College of Medicine / Lingzhi Li, PhD | Young Investigator Grants | 2024 | Texas |
Improving homing and activity of CAR T cells in pediatric sarcomas | University of Colorado Denver / Joselyn Cruz Cruz, PhD | Young Investigator Grants | 2024 | Colorado |
Vaccine-boosted CAR T cell therapy for high risk neuroblastoma | Children’s Hospital of Philadelphia / Timothy Spear, MD/PhD | Young Investigator Grants | 2024 | Pennsylvania |
Capitalizing on functional genomics with targeted protein degradation in neuroblastoma | St. Jude Children’s Research Hospital / Ian Delahunty, PhD | Young Investigator Grants | 2024 | Tennessee |
Defining how thymic expression of oncofetal antigens hinders the efficacy of pediatric-cancer focused immunotherapies | Stanford University / Adrienne Long, MD/PhD | Young Investigator Grants | 2024 | California |
In vivo transdermal generation of CD33 CAR T-cells towards acute myeloid leukemia | University of California, Los Angeles / Ruby Sims, PhD | Young Investigator Grants | 2024 | California |
Modifying CAR T cell epigenetic programs to improve therapy against aggressive pediatric brain tumors | St. Jude Children’s Research Hospital / Meghan Ward, PhD | Young Investigator Grants | 2024 | Tennessee |
Understanding the role of CDK8 in protein synthesis for treating MYC-driven medulloblastoma | University of Colorado Denver / Dong Wang, PhD | Young Investigator Grants | 2024 | Colorado |
Unraveling GABAergic interneuron-like lineage in H3G34-mutant hemispheric high-grade gliomas: their impact on network formation and invasion | Dana-Farber Cancer Institute / Gustavo Alencastro Veiga Cruzeiro, PhD | Young Investigator Grants | 2024 | Massachusetts |
Exploiting a Novel DNA Repair Defect in Ewing Sarcoma | Dana-Farber Cancer Institute / Shuhei Asada, MD/PhD | Young Investigator Grants | 2024 | Massachusetts |
Novel mechanisms and therapeutic targeting of chemoresistant rhabdomyosarcoma | Massachusetts General Hospital / Yueyang Wang, PhD | Young Investigator Grants | 2024 | Massachusetts |
Investigating the impact of osteosarcoma genetic lesions on bone differentiation | Dana-Farber Cancer Institute / James Morrow, MD/PhD | Young Investigator Grants | 2024 | Massachusetts |
The influence of the raphe nucleus and serotonin on progression of diffuse intrinsic pontine glioma | Stanford University / Richard Drexler, MD/PhD | Young Investigator Grants | 2024 | California |
Targeting the Checkpoint Receptor TIGIT via CRISPR/Cas9 Genome Editing to Enhance NK Cell Anti-Tumor Activity | Research Institute at Nationwide Children's Hospital / Amanda Campbell, MD/PhD | Young Investigator Grants | 2023 | Ohio |
Identifying Ewing Sarcoma Developmental Vulnerabilities | Children’s Hospital Los Angeles / Elena Vasileva, PhD | Young Investigator Grants | 2023 | California |
Pre-Targeted Radioimmunotherapy for Desmoplastic Small Round Cell Tumors | Memorial Sloan-Kettering Cancer Center / Madelyn Espinosa-Cotton, PhD | Young Investigator Grants | 2023 | New York |
Mechanisms of BRAF Activation in KIAA1549-BRAF Mutant pLGGs | Broad Institute / Sean Misek, PhD | Young Investigator Grants | 2023 | Massachusetts |
CDK8 as a New Therapeutic Target in Alveolar Rhabdomyosarcoma | Dana-Farber Cancer Institute / Susu Zhang, PhD | Young Investigator Grants | 2023 | Massachusetts |
Identifying Therapeutic Vulnerabilities in Pediatric AML through Investigation of the MECOM Transcriptional Network | Boston Children’s Hospital / Richard Voit, MD/PhD | Young Investigator Grants | 2023 | Massachusetts |
Synthetic Gene Expression Regulatory Switches (SynGERS) for Improved CAR T Cell Function in Pediatric Solid Tumors | Baylor College of Medicine / Leidy Diana Caraballo Galva, PhD | Young Investigator Grants | 2023 | Texas |
Radiation and the Tumor Microenvironment in an Immunocompetent Model of Ewing Sarcoma | Children’s Hospital of Pittsburgh Foundation / Jessica Daley, MD | Young Investigator Grants | 2023 | Pennsylvania |
Elucidating the Roles of Aneuploidy in Down Syndrome-Associated Leukemia | Boston Children’s Hospital / Chun-Chin Chen, PhD | Young Investigator Grants | 2023 | Massachusetts |
Arginine Depletion with DFMO in High-Risk Neuroblastoma | Children’s Hospital of Philadelphia / Christina Turn, MD | Young Investigator Grants | 2023 | Pennsylvania |
A Novel Adjunctive LAT-Activating CART (ALA-CART) Cell Platform for the Treatment of Acute Leukemia | University of Colorado Denver_ Anschutz Medical Campus / Catherine Danis, PhD | Young Investigator Grants | 2023 | Colorado |
Targeting Oncogenic N-MYC Complexes in High-Risk Neuroblastoma | The Regents of the University of California San Francisco / Bo Qiu, MD/PhD | Young Investigator Grants | 2023 | California |
Ex Vivo Modeling of Medulloblastoma using Human iPSC-Derived Cerebellar Organoids | St. Jude Children’s Research Hospital / Stephanie Wu, PhD | Young Investigator Grants | 2023 | Tennessee |
The Role of LIN28B-let-7-PBK Axis on the Growth and Metastasis of Group 3 Medulloblastoma | Emory University / Shubin Shahab, MD/PhD | Young Investigator Grants | 2021 | Georgia |
Exploiting the Potential of Bromodomain Inhibitors in Ewing Sarcoma | Seattle Children’s Hospital / Shireen Ganapathi, MD | Young Investigator Grants | 2021 | Washington |
Dissecting the Contribution and Inheritance of Germline DNA Damage Repair Gene Mutations in Neuroblastoma | Dana-Farber Cancer Institute / Riaz Gillani, MD | Young Investigator Grants | 2021 | Massachusetts |
Dissecting Functional uORFs as a Source of Cancer Genes in High-Risk Medulloblastoma | Dana-Farber Cancer Institute / John Prensner, MD/PhD | Young Investigator Grants | 2021 | Massachusetts |
Social Determinants of Health, Hospital-level Resources, and Risk of Septic Shock in Pediatric Leukemia | Children’s Hospital of Philadelphia / Jenny Ruiz, MD | Young Investigator Grants | 2021 | Pennsylvania |
Redefining Osteosarcoma Metastases as Chronic Non-healing Lung Wounds: Implications for Developing Novel Therapies | Research Institute at Nationwide Children's Hospital / James Reinecke, MD/PhD | Young Investigator Grants | 2021 | Ohio |
Activating Metabolic Pathways to Increase the Persistence of Leukemia Targeting T Cells | Children’s Hospital of Pittsburgh / Erica Braverman, MD | Young Investigator Grants | 2021 | Pennsylvania |
STING Pathway Activation: The Missing Link between Genomic Instability and Antitumor Immunity in Osteosarcoma | University of California San Francisco / Elizabeth Young, MD | Young Investigator Grants | 2021 | California |
Hematopoietic Stem And Progenitor Cells Sustain Inflammation And Promote Relapse In The AML Niche | Children’s Hospital of Philadelphia / Ding-Wen (Roger) Chen, PhD | Young Investigator Grants | 2021 | Pennsylvania |
Investigating Epigenetic Mechanisms of Response to Allogenic CAR T Cell Therapy | St. Jude Children’s Research Hospital / Caitlin Zebley, MD/PhD | Young Investigator Grants | 2021 | Tennessee |
Neural Crest Gene Regulatory Networks Underlying Normal Meningeal Development and Onset of Meningioma | California Institute of Technology / Ayyappa Raja Desingu Rajan, PhD | Young Investigator Grants | 2021 | California |
Function and Dependency of NFkB Activity in ZFTA-RELA Fusion Ependymoma | Baylor College of Medicine / Austin Stuckert, MD | Young Investigator Grants | 2021 | Texas |
Dissecting the Role of FOXR2 in the Oncogenesis of Diffuse Intrinsic Pontine Glioma | Dana-Farber Cancer Institute / Jessica Tsai, MD/PhD | Young Investigator Grants | 2020 | Massachusetts |
Using Neurofibromatosis-1 (NF1) to understand Pediatric Brain Tumor Initiation | MD Anderson Cancer Center / Yuan Pan, PhD | Young Investigator Grants | 2020 | Texas |
High-throughput CAR NKT Library Screen for Improving Neuroblastoma Immunotherapy | Baylor College of Medicine / Xavier Rios, MD/PhD | Young Investigator Grants | 2020 | Texas |
Donor T-Cell DNA Methylation in GVHD and the Graft-vs-Tumor Effect after Allogeneic Hematopoietic Stem Cell Transplant | The Johns Hopkins University School of Medicine / Yiouli Panayiota Ktena, MD | Young Investigator Grants | 2020 | Maryland |
Novel Synergistic Targets for Combination Therapy in Philadelphia Chromosome-like Acute Lymphoblastic Leukemia | Children’s Hospital of Philadelphia / Yang Ding, MD | Young Investigator Grants | 2020 | Pennsylvania |
Identifying Epistatic Suppressors of Oncohistone in Pediatric High-Grade Gliomas | BC Cancer (Provincial Health Services Authority) / Carol Chen, PhD | Young Investigator Grants | 2020 | British Columbia |
Modeling the Initiation and Progression of Down Syndrome Associated Leukemia Using CRISPR/Cas9 at Single Cell Resolution | Icahn School of Medicine at Mount Sinai / Elvin Wagenblast, PhD | Young Investigator Grants | 2020 | New York |
GPC2 CAR T Cell Targeted Delivery of BiKEs in High-Risk Neuroblastoma | Children’s Hospital of Philadelphia / Guillem Pascual-Pasto, PhD | Young Investigator Grants | 2020 | Pennsylvania |
Targeting the Rac GTPase Pathway to Sabotage RAS Signaling in RAS-mutated Leukemia | Boston Children’s Hospital / Sara Canovas Nunes, PhD | Young Investigator Grants | 2020 | Massachusetts |
Novel Genomic Drivers in Pediatric Polyposis Syndromes | Children’s Hospital of Philadelphia / Suzanne MacFarland, MD | Young Investigator Grants | 2019 | Pennsylvania |
The Role of Germline Variants in Infant Leukemogenesis | Washington University / Margaret Ferris, MD/PhD | Young Investigator Grants | 2019 | Missouri |
ECM-targeted CAR T-cell therapy for high-grade glioma | St. Jude Children’s Research Hospital / Jessica Wagner, PhD | Young Investigator Grants | 2019 | Tennessee |
Targeted Hyperactivation of PI3K/AKT in B-cell malignancies | Dana-Farber Cancer Institute / Vishal Khairnar, PhD | Young Investigator Grants | 2019 | Massachusetts |
Targeting TGFb Pathway Dependencies in Group 3 Medulloblastoma | University of California San Francisco / Zulekha Qadeer, PhD | Young Investigator Grants | 2019 | California |
Improving CAR T-Cell Therapy for Pediatric Osteosarcoma by Manipulating Arginine Metabolism | St. Jude Children’s Research Hospital / Shannon Lange, PhD | Young Investigator Grants | 2019 | Tennessee |
Identification of Synthetically Immunogenic Compounds to Synergize with Immunotherapy in Neuroblastoma | Children’s Hospital of Philadelphia / Adam Wolpaw, MD/PhD | Young Investigator Grants | 2019 | Pennsylvania |
The Impact Of CD56neg NK Cells in the Pathogenesis of Endemic Burkitt Lymphoma | University of Massachusetts Medical School / Catherine Forconi, PhD | Young Investigator Grants | 2019 | Massachusetts |
Targeting Valine-Specific Amino Acid Dependency -in T-Cell Acute Lymphoblastic Leukemia | New York University School of Medicine / Palaniraja Thandapani, PhD | Young Investigator Grants | 2019 | New York |
Enhancing the therapeutic efficacy of chimeric antigen receptor T cells for acute myeloid leukemia | Washington University / Miriam Kim, MD | Young Investigator Grants | 2019 | Missouri |
Characterization of Chromatin Landscapes to Identify Therapeutic Vulnerabilities in Diffuse Midline Gliomas. | Fred Hutchinson Cancer Research Center / Jay Sarthy, MD/PhD | Young Investigator Grants | 2019 | Washington |
Modeling H3 G34R and BCOR-Altered Glioma Pathogenesis Using Neural Stem Cells | The Johns Hopkins University School of Medicine / Satoshi Nakata, MD/PhD | Young Investigator Grants | 2019 | Maryland |
Kidney Disease after CD19-Targeted Chimeric Antigen Receptor T Cell Therapy for Pediatric Acute Lymphoblastic Leukemia | Children’s Hospital of Philadelphia / Regina Myers, MD | Young Investigator Grants | 2019 | Pennsylvania |
MLL Oncogene-Dependent Enhancer Reprogramming Promotes Leukemogenesis | Stanford University / Feng Pan, PhD | Young Investigator Grants | 2019 | California |
The Role of Tumor Heterogeneity in Relapse of Pediatric Acute Myeloid Leukemia | Children’s Hospital & Research Center at Oakland / Cheryl Peretz, MD | Young Investigator Grants | 2019 | California |
Investigation of Pediatric Rhabdomyosarcoma Recurrence through Single-Cell Sequencing | St. Jude Children’s Research Hospital / Anand Patel, MD/PhD | Young Investigator Grants | 2019 | Tennessee |
Defining the Molecular Mechanisms Underlying Pediatric Brain Tumor Penetrance | Washington University / Nicole Brossier, MD/PhD | Young Investigator Grants | 2019 | Missouri |
Bcl2-Family Inhibitors in Neuroblastoma: Mechanism of Action, Therapy Resistance, and Development of Biomarkers | Children’s Hospital of Philadelphia / Claudia Zapata, MD | Young Investigator Grants | 2019 | Pennsylvania |
Therapeutic Targets and Molecular Mechanisms in Childhood Brainstem Tumors | University Health Network - Toronto Western Research Institute / Jerome Fortin, PhD | Young Investigator Grants | 2019 | Ontario |
Therapeutic Targeting of Childhood Leukemia by Pharmacological Inhibition of Proteolytic Cleavage of MLL1 | Northwestern University (Illinois) / Zibo Zhao, PhD | Young Investigator Grants | 2018 | Illinois |
NUDT15 Polymorphisms and Individualization of Thiopurine Therapy in Children with Acute Lymphoblastic Leukemia | St. Jude Children’s Research Hospital / Takaya Moriyama, MD/PhD | Young Investigator Grants | 2018 | Tennessee |
Modeling GATA2 Associated MDS/AML Predisposition Syndrome Using Color-Barcoding and Mutagenesis in Zebrafish | Dana-Farber Cancer Institute / Serine Avagyan, PhD | Young Investigator Grants | 2018 | Massachusetts |
Investigating the role of BAI1 in the Metastasis of Medulloblastoma | University of Alabama at Birmingham / Satoru Osuka, MD/PhD | Young Investigator Grants | 2018 | Alabama |
Effect of SLCO Polymorphisms on High-Dose Methotrexate Clearance in Pediatric Oncology Patients | Vanderbilt University Medical Center / Rachael Schulte, MD | Young Investigator Grants | 2018 | Tennessee |
Targeting the Metabolic Drivers of Chemo Resistance in Acute Myeloid Leukemia | Harvard University / Nick van Gastel, PhD | Young Investigator Grants | 2018 | Massachusetts |
Augmenting Chimeric Antigen Receptor T Cell Induced Epitope Spreading for Pediatric Solid Tumors | Children’s Hospital of Philadelphia / Michael Leibowitz, MD/PhD | Young Investigator Grants | 2018 | Pennsylvania |
Divergent Core Transcriptional Regulatory Circuitries to Highlight Context-Specific Vulnerabilities in AML | Dana-Farber Cancer Institute / Maxim Pimkin, MD/PhD | Young Investigator Grants | 2018 | Massachusetts |
MYC-driven Core Regulatory Circuits in Neuroblastoma | Dana-Farber Cancer Institute / Mark Zimmerman, PhD | Young Investigator Grants | 2018 | Massachusetts |
Describing the Biological Impacts of Gain-of-function SAMD9 Mutations | Vanderbilt University Medical Center / Jason Schwartz, MD/PhD | Young Investigator Grants | 2018 | Tennessee |
Novel Antibodies to the C2-set Domain of CD33 for Acute Myeloid Leukemia Immunotherapy | Fred Hutchinson Cancer Research Center / Colin Godwin, MD | Young Investigator Grants | 2018 | Washington |
Accessing Combinatorial Effect of PARP Inhibitor with DNA Damaging Agent in Rhabdomyosarcoma at Single Cell Resolution | Massachusetts General Hospital / Chuan Yan, PhD | Young Investigator Grants | 2018 | Massachusetts |
Cooperating Signaling Networks Regulate Cell Survival of Pediatric Ph-like ALL | University of Pennsylvania / Christian Hurtz, PhD | Young Investigator Grants | 2018 | Pennsylvania |
Beyond Febrile Neutropenia: Risks Associated with Antibiotic Choice in Children with Leukemia that Undergo Transplant | Children’s Hospital of Philadelphia / Caitlin Elgarten, MD | Young Investigator Grants | 2018 | Pennsylvania |
Pedi-PRESTO: Pediatric Patient-Reported Symptom Tracking in Oncology | Children’s Hospital of Philadelphia / Allison Barz Leahy, MD | Young Investigator Grants | 2018 | Pennsylvania |
Interrogation of Neuroblastoma Dependencies and RNAs on the Core-Regulatory Circuitry for Therapeutic Inhibition | St. Jude Children’s Research Hospital / Adam Durbin, PhD | Young Investigator Grants | 2018 | Tennessee |
Development and Characterization of Novel Models of Human Osteosarcoma Development and Metastasis | University of Minnesota / Beau Webber, PhD | Young Investigator Grants | 2017 | Minnesota |
The Impact of Hypoxia on Epigenetic Changes in Neuroblastoma | University of Chicago / Sakshi Uppal, PhD | Young Investigator Grants | 2017 | Illinois |
Overcoming Glucocorticoid Resistance in Lymphoid Cancers | University of California San Francisco / Anica Wandler, PhD | Young Investigator Grants | 2017 | California |
High-Throughput Gene-Editing via Microfluidic Cell Deformability to Enable Off-the-Shelf Allogeneic Cellular Immunotherapies | University of California, Los Angeles / Steven Jonas, MD/PhD | Young Investigator Grants | 2017 | California |
Targeting Glutamine Metabolism in MYC Driven Atypical Teratoid Rhabdoid Tumors | The Johns Hopkins University School of Medicine / Jeffrey Rubens, MD | Young Investigator Grants | 2017 | Maryland |
Anthracycline-Induced Cardiac Toxicity in Pediatric Acute Myeloid Leukemia | University of Pennsylvania / Kelly Getz, PhD | Young Investigator Grants | 2017 | Pennsylvania |
Epigenomic Mechanisms of Neuroblastoma Tumorigenesis | Children’s Hospital of Philadelphia / Jo Lynne Harenza, PhD | Young Investigator Grants | 2017 | Pennsylvania |
Targeting Protein Translation to Antagonize MYC-driven Neuroblastoma | Children’s Hospital of Philadelphia / Andrea Flynn, MD | Young Investigator Grants | 2017 | Pennsylvania |
Preclinical Efficacy of Daratumumab in T Cell Acute Lymphoblastic Leukemia | New York University School of Medicine / Karen Bride, MD/PhD | Young Investigator Grants | 2017 | New York |
End-of-Life Care of Children with Cancer: Variation and Stakeholder Priorities | University of Alabama at Birmingham / Emily Johnston, MD | Young Investigator Grants | 2017 | Alabama |
Identification and Targeting of Microenvironmental Factors Controlling Pediatric Leukemia | New York University School of Medicine / Anastasia Tikhonova, PhD | Young Investigator Grants | 2017 | New York |
Identification and Characterization of Pathways Dysregulated by MMSET E1099K Mutation in Relapsed Pediatric Acute Lymphoblastic Leukemia and Their Role in Drug Resistance | New York University School of Medicine / Joanna Pierro, DO | Young Investigator Grants | 2017 | New York |
Elucidating the Role of N-Myc in a High-risk Pediatric T Cell Leukemia | New York University School of Medicine / Francesco Boccalatte, PhD | Young Investigator Grants | 2017 | New York |
Cancer Susceptibility and Signaling Pathways in Low-Grade Brain Tumors | Jewish General Hospital / Bárbara Rivera, PhD | Young Investigator Grants | 2017 | Quebec |
Identifying Disease Mechanisms and Therapeutic Opportunities in Pediatric Low-grade Gliomas Driven by MYB-QKI Fusions | Dana-Farber Cancer Institute / Cecile Rouleau, PhD | Young Investigator Grants | 2017 | Massachusetts |
Development of Novel Biomarkers for Immunotherapy in Neuroblastoma | Columbia Institute for Cancer Genetics / Shuobo Boboila, PhD | Young Investigator Grants | 2017 | New York |
Understanding the Mechanisms of HOX Gene Regulation in Normal and Leukemic Hematopoietic Stem Cells to Identify New Therapies for Pediatric AML | Boston Children’s Hospital / Anne Robertson, PhD | Young Investigator Grants | 2017 | Massachusetts |
Role of N6-Methyladenosine (m6A) mRNA Modification Pathway in Neuroblastoma | Boston Children’s Hospital / Shuibin Lin, PhD | Young Investigator Grants | 2017 | Massachusetts |
Identification of Mechanisms of Resistance to Trametinib Monotherapy in PAX-fusion Negative Rhabdomyosarcoma | National Cancer Institute / Marielle Yohe, MD/PhD | Young Investigator Grants | 2016 | Maryland |
Investigating Racial Disparities in Pediatric Acute Leukemia | University of California San Francisco / Lena Winestone, MD | Young Investigator Grants | 2016 | California |
Targeting Eya2 to Inhibit c-Myc driven Medulloblastoma Tumor Progression | University of Colorado Denver / Melanie Vincent, PhD | Young Investigator Grants | 2016 | Colorado |
A CRISPRi Genetic Screen in Ewing sarcoma Identifies a Novel Dependence on Homologous Recombination DNA Repair | University of California San Francisco / Asmin Tulpule, MD/PhD | Young Investigator Grants | 2016 | California |
Resistance and Develop Improved Treatments for Relapsed/refractory Pediatric ALL | Dana-Farber Cancer Institute / Elizabeth Townsend, PhD | Young Investigator Grants | 2016 | Massachusetts |
Bad Influence: EWS/FLI Alters LSD1 and NuRD Interactions to Enforce Oncogenic Function in Ewing’s | Research Institute at Nationwide Children's Hospital / Emily Theisen, PhD | Young Investigator Grants | 2016 | Ohio |
The Role of ARID1A in Neuroblastoma Pathogenesis | Dana-Farber Cancer Institute / Hui Shi, PhD | Young Investigator Grants | 2016 | Massachusetts |
Role of Kindlin-3 In Natural Killer Cell Mediated Tumor Killing | Children’s Hospital of Wisconsin - Milwaukee / Nathan Schloemer, MD | Young Investigator Grants | 2016 | Wisconsin |
Elucidating the Role of Human FAN1 Nuclease in DNA Crosslink Repair | Yale School of Medicine / Timsi Rao, PhD | Young Investigator Grants | 2016 | Connecticut |
Pre-clinical Evaluation of LSD1 Inhibitors for the Treatment of Pediatric Ewing sarcoma: Defining the Biomarkers of Sensitivity and Mechanisms of Resistance | Research Institute at Nationwide Children's Hospital / Kathleen Pishas, PhD | Young Investigator Grants | 2016 | Ohio |
Interrogating the Enhancer Landscapes of Ependymoma to Inform Novel Therapies | Baylor College of Medicine / Stephen Mack, PhD | Young Investigator Grants | 2016 | Texas |
Single-cell RNA-seq Profiling of Transcriptional Transition States During Human Retinoblastoma | Children’s Hospital Los Angeles / Sunhye Lee, PhD | Young Investigator Grants | 2016 | California |
Genetically Engineered T Cells as Therapy for Pediatric Glioma | Baylor College of Medicine / Giedre Krenciute, PhD | Young Investigator Grants | 2016 | Texas |
A Role for Non-canonical Wnt/PCP Signaling in Growth and Self-Renewal of Embryonal Rhabdomyosarcoma | Massachusetts General Hospital / Madeline Hayes, PhD | Young Investigator Grants | 2016 | Massachusetts |
Variation in Care and Outcomes in Pediatric Acute Leukemia | Children’s Hospital of Philadelphia / Amanda DiNofia, MD | Young Investigator Grants | 2016 | Pennsylvania |
Molecular Basis of ALK Inhibition Resistance in High-risk Neuroblastoma | Dana-Farber Cancer Institute / David Debruyne, PhD | Young Investigator Grants | 2016 | Massachusetts |
The Role of MiRNA Impairment in Wilms' Tumor Formation | University of Texas Southwestern Medical Center at Dallas / Kenneth Chen, MD | Young Investigator Grants | 2016 | Texas |
GPC2 as an Oncogene and Immunotherapeutic Target in High-risk Neuroblastoma | Children’s Hospital of Philadelphia / Kristopher Bosse, MD | Young Investigator Grants | 2016 | Pennsylvania |
Developing Targeted Immunotherapy Against Pediatric Acute Myeloid Leukemia | Fred Hutchinson Cancer Research Center / Melinda Biernacki, MD | Young Investigator Grants | 2016 | Washington |
Micro-environmental Regulators of Ewing sarcoma Metastasis | University of Pittsburgh / Kelly Bailey, MD/PhD | Young Investigator Grants | 2016 | Pennsylvania |
CD19 Delta Ex2 Isoform as a Target for Alternative Therapies in Relapsed Pediatric B-ALL | Children’s Hospital of Philadelphia / Asen Bagashev, PhD | Young Investigator Grants | 2016 | Pennsylvania |
Targeting Metabolism as a Therapeutic Approach for High-Risk MYCN-Driven Neuroblastoma | University of Pennsylvania / Nicole Anderson, PhD | Young Investigator Grants | 2016 | Pennsylvania |
Novel Nanoscale Phosphoproteomic Discovery of Therapeutic Targets in AML Stem Cells | Dana-Farber Cancer Institute / Leo Wang, MD, PhD | Young Investigator Grants | 2015 | Massachusetts |
The Role of DEF and SSU Processome in Neuroblastoma Pathogenesis | Dana-Farber Cancer Institute / Ting Tao, PhD | Young Investigator Grants | 2015 | Massachusetts |
CAMKV as a Target for Immunotherapy in MYCN-Amplified Neuroblastoma | Children’s Hospital of Philadelphia / Robyn Sussman, PhD | Young Investigator Grants | 2015 | Pennsylvania |
Targeting Secondary Mutations in Juvenile Myelomonocytic Leukemia | University of California San Francisco / Elliot Stieglitz, MD | Young Investigator Grants | 2015 | California |
Enhancing the Viability, Function, and Safety, of Genetically-Enhanced NK Cells Within the Solid Tumor Microenvironment With IL-15 and a Suicide Gene | Baylor College of Medicine / Robin Parihar, MD, PhD | Young Investigator Grants | 2015 | Texas |
Zebrafish Modeling of PAX3-FOXO1 Driven Rhabdomyosarcoma | University of Texas Southwestern Medical Center / Genevieve Kendall, PhD | Young Investigator Grants | 2015 | Texas |
Elucidating Mechanisms Driving Renal Medullary Carcinomas to Deliver a Rational Approach to Cancer Directed Therapy | Dana-Farber Cancer Institute / Andrew Hong, MD | Young Investigator Grants | 2015 | Massachusetts |
Functional Dissection of Oncogenic Enhancers in T-ALL | Columbia University / Daniel Herranz, PhD | Young Investigator Grants | 2015 | New York |
Critical Contributions of CRM1 to Leukemogenesis | University of Vermont / Jessica Linda Heath, MD | Young Investigator Grants | 2015 | Vermont |
A Translational Approach to Identify Drugs with Specific Activity Against EZH2 Mutant High Risk T-ALLs and ETP ALLs that Overexpress the JDP2 bZIP Transcription Factor | Dana-Farber Cancer Institute / Shuning He, PhD | Young Investigator Grants | 2015 | Massachusetts |
The Effect of Locus of Care Upon Adolescent and Young Adults Cancer Outcomes: An IMPACT Cohort Study | Hospital for Sick Children / Sumit Gupta, MD, PhD | Young Investigator Grants | 2015 | Ontario |
Novel Role of Hematopoietic Stem Cells in Immunologic Rejection of Malignant Pediatric Brain Tumors | University of Florida / Catherine Flores, PhD | Young Investigator Grants | 2015 | Florida |
Genetic Dissection of Cancer Drug Resistance and Toxicity Using Haploid Human Cells | Stanford University / Ramin Dubey, PhD | Young Investigator Grants | 2015 | California |
The YB1 Way of Surviving Radiation, Pediatric Brain Tumor Resistance and Recurrence | Emory University / Abhinav Dey, PhD | Young Investigator Grants | 2015 | Georgia |
Engager T Cells: A Novel Immunotherapeutic for AML | University of Michigan / Challice Bonifant, MD, PhD | Young Investigator Grants | 2015 | Michigan |
Regulation of Hematopoietic Stem Cell Engraftment by the Endothelial Cell Niche | Boston Children’s Hospital / Bradley Blaser, MD, PhD | Young Investigator Grants | 2015 | Massachusetts |
The Role of PARP3 in the Formation of Chromosomal Translocations | Dana-Farber Cancer Institute / Tovah Day, PhD | Young Investigator Grants | 2015 | Massachusetts |
The Cebpa Downstream Enhancer as a Key Target of Transformation to Acute Myeloid Leukemia | The Johns Hopkins University School of Medicine / Stacy Cooper, MD | Young Investigator Grants | 2015 | Maryland |
Elucidating the Mechanism of ERK Mediated Pathogenesis of LCH | Baylor College of Medicine / Rikhia Chakraborty, PhD | Young Investigator Grants | 2015 | Texas |
Chemical Genetics and CRISPRi/a Screen for Novel Therapeutic Targets in a Humanized Model for MYCN Associated High-Risk Pediatric Neuroblastoma | University of California San Francisco / Zhenyi An, PhD | Young Investigator Grants | 2015 | California |
Understanding the Role of Translational Control in Humanized Mouse Models for Medulloblastoma | University of California San Francisco / Ozlem Aksoy, PhD | Young Investigator Grants | 2015 | California |
Exosomes as Biomarkers to Monitor Disease Progression and Response to Therapy in Ewing sarcoma | Children’s Mercy / Glenson Samuel, MD | Young Investigator Grants | 2014 | Missouri |
Hospital Volume and Induction Mortality in Children, Adolescents, and Young Adults with Acute Leukemia | Children’s Hospital of Philadelphia / Jennifer Wilkes, MD | Young Investigator Grants | 2014 | Pennsylvania |
Optimizing Engager T-cells for CD19+ Malignancies | Baylor College of Medicine / Mireya Paulina Velasquez, MD | Young Investigator Grants | 2014 | Texas |
Identification of Resistance Mechanisms and Novel Therapeutic Strategies in Tyrosine Kinase Inhibitor Resistant FLT3/ITD Acute Myeloid Leukemia | Fred Hutchinson Cancer Research Center / Katherine Tarlock, MD | Young Investigator Grants | 2014 | Washington |
Targeting Aberrant Hh Signaling with BET Bromodomain Inhibition as a Novel Therapeutic Strategy Against MB and DIPG | Lucile Packard Children’s Hospital at Stanford University School of Medicine / Yujie Tang, PhD | Young Investigator Grants | 2014 | California |
Understanding and Preventing Healthy Tissue Damage in Pediatric Cancer Patients | Dana-Farber Cancer Institute / Kristopher Sarosiek, PhD | Young Investigator Grants | 2014 | Massachusetts |
Deciphering the Mechanisms of Medulloblastoma Treatment Resistance using Integrative Genomics | Hospital for Sick Children / Vijay Ramaswamy, MD | Young Investigator Grants | 2014 | Ontario |
Targeted Therapy for Core Binding Factor Leukemia | University of Massachusetts Medical School / John Pulikkan, PhD | Young Investigator Grants | 2014 | Massachusetts |
Translating BET Bromodomain Inhibitors for Acute Myeloid Leukemia Therapy | Dana-Farber Cancer Institute / Yana Pikman, MD | Young Investigator Grants | 2014 | Massachusetts |
Investigation of Oncogenic Long Non-coding RNAs in Ewing sarcoma | Lucile Packard Children’s Hospital at Stanford University School of Medicine / Siu Ping Ngok, PhD | Young Investigator Grants | 2014 | California |
Autophagy and mTOR Inhibition in Pediatric Gliomas with BRAF Mutations | University of Colorado Denver / Jean Mulcahy Levy, MD | Young Investigator Grants | 2014 | Colorado |
Ca2+ Release Activated Ca2+ (CRAC) Channels in Control of Leukemic Cell Metabolism and Leukemia Stem Cell Maintenance in T-ALL | New York University School of Medicine / Mate Maus, PhD | Young Investigator Grants | 2014 | New York |
SETD2 Mutations in Prognosis and Chemotherapy Resistance in Relapsed Acute Lymphoblastic Leukemia | Dana-Farber Cancer Institute / Brenton Mar, MD, PhD | Young Investigator Grants | 2014 | Massachusetts |
Mechanisms of CNOT3 Tumor Suppression in T-ALL and Identification of New Drugs That Specifically Kill CNOT3-Deficient T-ALL Cells | Dana-Farber Cancer Institute / Zhaodong Li, PhD | Young Investigator Grants | 2014 | Massachusetts |
Development of Targeted DNA-damaging Therapy for ATRX-deficient Pediatric Glioblastoma | University of Michigan / Carl Koschmann, MD | Young Investigator Grants | 2014 | Michigan |
Molecular Mechanism and Development of Therapeutic Strategies Targeting MYCN-induced Calcium Signaling in Advanced Neuroblastoma | University of Hawaii at Hilo / Ingo Koomoa-Lange, PhD | Young Investigator Grants | 2014 | Hawaii |
A Developmental Model to Characterize the Epigenetic Origins of the Retinoblastoma Tumor Initiating Cell | The Johns Hopkins University School of Medicine / Jeffrey Huo, MD, PhD | Young Investigator Grants | 2014 | Maryland |
Immunotherapy Of Neuroblastoma With Natural Killer T Cells Engineered To Target O-acetyl-GD2 | Baylor College of Medicine / Andras Heczey, MD | Young Investigator Grants | 2014 | Texas |
Niche for in Vitro Generation of Hematopoietic Stem Cells from Pluripotent Stem Cells | Fred Hutchinson Cancer Research Center / Brandon Hadland, MD, PhD | Young Investigator Grants | 2014 | Washington |
APOBEC3 in Pediatric Leukemia: a Biomarker for Sensitivity to PARP Inhibition? | Children’s Hospital of Philadelphia / Abby Green, MD | Young Investigator Grants | 2014 | Pennsylvania |
Targeting the Thymic Stromal Lymphopoeitin Receptor Signaling Axis to Reduce Relapse of High Risk Pediatric Acute Lymphoblastic Leukemia | National Cancer Institute / Christopher Chien, PhD | Young Investigator Grants | 2014 | Maryland |
Targeting the Epigenome of Diffuse Intrinsic Pontine Glioma | The Johns Hopkins University School of Medicine / Sama Ahsan, MD | Young Investigator Grants | 2014 | Maryland |
Epigenetic Regulation of T cell Activation and Immunotherapy | The Johns Hopkins University School of Medicine / Brian Ladle, MD, PhD | Young Investigator Grants | 2013 | Maryland |
Oncogenic Hedgehog Pathway Activation by a Putative Rho GTPase-Activating Protein | Lucile Packard Children’s Hospital at Stanford University School of Medicine / Jun Ni, PhD | Young Investigator Grants | 2013 | California |
Histone Modification and Hmgn1 Overexpression as Drivers of B-ALL with Polysomy 21 | Dana-Farber Cancer Institute / Andrew Lane, MD, PhD | Young Investigator Grants | 2013 | Massachusetts |
The Role of PTPRD as a Tumor Suppressor in Neuroblastoma Pathogenesis | Mayo Clinic / Shizhen Zhu, MD, PhD | Young Investigator Grants | 2013 | Minnesota |
The Role of Prmt1 in Osteosarcoma Initiation and Metastasis | Dana-Farber Cancer Institute / Hao-Ru Hsu, PhD | Young Investigator Grants | 2013 | Massachusetts |
Defining the Mechanism by which LIN28B acts as an Oncogene in Neuroblastoma | Children’s Hospital of Philadelphia / Robert Schnepp, MD, PhD | Young Investigator Grants | 2013 | Pennsylvania |
LRP1 and Angiogenesis in Pediatric Malignant Glioma | Mayo Clinic Jacksonville / Takahisa Kanekiyo, MD, PhD | Young Investigator Grants | 2013 | Florida |
PRL3 as a Novel Therapeutic Target for Relapsed T-cell Acute Lymphoblastic Leukemia | Massachusetts General Hospital / Jessica Blackburn, PhD | Young Investigator Grants | 2013 | Massachusetts |
Dissecting and Targeting the Wnt Signaling Pathway in Metastatic Osteosarcoma | Baylor College of Medicine / Jason T. Yustein, MD, PhD | Young Investigator Grants | 2013 | Texas |
The Regulation of Hematopoietic Stem Cell Function by Granulocyte-Colony Stimulating Factor | Washington University / Laura Schuettpelz, MD, PhD | Young Investigator Grants | 2013 | Missouri |
Dissecting the Mechanism of Overgrowth and Tumorigenesis in Beckwith-Wiedemann Syndrome | University of Pennsylvania / Jennifer Kalish, MD, PhD | Young Investigator Grants | 2013 | Pennsylvania |
Multifunctional Nanomaterials for the Prevention of Radiotherapy's Side Effects and Childhood Cancers | Massachusetts General Hospital / Charalambos Kaittanis, PhD | Young Investigator Grants | 2013 | Massachusetts |
Genetic Profiling and Experimental Modeling of High-risk Acute Lymphoblastic Leukemia | St. Jude Children’s Research Hospital / Kathryn Roberts, PhD | Young Investigator Grants | 2013 | Tennessee |
Genomic Alterations in ETV6 Predict Outcome in Pediatric AML | Fred Hutchinson Cancer Research Center / Heather Helton, MD | Young Investigator Grants | 2013 | Washington |
Reversing the Oncogenic Roles of Misdirected Chromatin Remodeling in Synovial Sarcoma | Lucile Packard Children’s Hospital at Stanford University School of Medicine / Cigall Kadoch, PhD | Young Investigator Grants | 2013 | California |
Targeted Inhibition of Signaling Networks in Pediatric Glioblastoma Stem Cells | University of California Berkeley / Erin Simonds, PhD | Young Investigator Grants | 2013 | California |
Characterization of the Role of Chromosome 1p Deletion in MYCN-Amplified Neuroblastoma | University of California San Francisco / Miller Huang, PhD | Young Investigator Grants | 2013 | California |
Dissecting the Hierarchy of Tumor Cell Differentiation Using Dual Recombinase Technology in a Novel Mouse Model of Rhabdomyosarcoma | Duke University Medical Center / David Van Mater, MD, PhD | Young Investigator Grants | 2013 | North Carolina |
Investigating the Role of Circadian Rhythm in the Progression of Acute Myeloid Leukemia | Boston Children’s Hospital / Samantha Morris, PhD | Young Investigator Grants | 2013 | Massachusetts |
Genetic Dissection of Trisomy 21-TMD Using Human Pluripotent Stem Cells | Boston Children’s Hospital / Glenn MacLean | Young Investigator Grants | 2013 | Massachusetts |
Exploiting WT1 Genomic Alterations for Target Identification and MRD Monitoring in Pediatric AML | Fred Hutchinson Cancer Research Center / Phoenix Ho | Young Investigator Grants | 2012 | Washington |
Transcriptome Sequencing (RNA-Seq) for Identification of Novel Markers of Disease Outcome and Therapeutic Targets in Acute Myeloid Leukemia | Fred Hutchinson Cancer Research Center / Fabiana Ostronoff, MD | Young Investigator Grants | 2012 | Washington |
Role of Myosin VI in Pediatric Glioma Proliferation and Invasion | University of Pennsylvania / Monalisa Mukherjea | Young Investigator Grants | 2012 | Pennsylvania |
Development of Targeted Therapies in High Risk Childhood Acute Lymphoblastic Leukemia | Children’s Hospital of Philadelphia / Sarah Tasian | Young Investigator Grants | 2012 | Pennsylvania |
Small-molecule screening for novel pediatric glioma radiosensitizers. | Yale School of Medicine / Ranjit Bindra | Young Investigator Grants | 2012 | Connecticut |
Identifying Therapeutic Targets for MiT Associated Pediatric Cancers | Yale School of Medicine / Sean Landrette | Young Investigator Grants | 2012 | Connecticut |
Development of An Innovative Treatment Strategy for Neuroblastoma and Other Pediatric Tumors: A Novel Phospholipid Ester Analogue and its Multifunctional Cancer-targeting Nanoconstruct | University of Wisconsin - Madison / Mario Otto | Young Investigator Grants | 2012 | Wisconsin |
Determinants of Testicular Germ Cell Tumor Platinum Sensitivity and Resistance | University of California, San Diego / Paolo Abada | Young Investigator Grants | 2012 | California |
Adoptive Cell Therapy Targeting Antigen Escape Variants in Childhood High Grade Glioma | Baylor College of Medicine / Meenakshi Hegde | Young Investigator Grants | 2012 | Texas |
Treatment for human hepatoblastoma based on recombinant adeno-associated virus vectors | University of Florida / Chen Ling | Young Investigator Grants | 2012 | Florida |
Screening for New Rhabdomyosaroma Pathogenesis Genes in a Drosophila Model | University of Texas Southwestern Medical Center / Kathleen Galindo | Young Investigator Grants | 2012 | Texas |
Epigenetic regulation of self-renewal pathways in hematopoietic and leukemic stem cells | George Washington University / Alexandros Tzatsos, MD/PhD | Young Investigator Grants | 2012 | District of Columbia |
SWI/SNF Complex and Glucocorticoid Resistance in Pediatric Acute Lymphoblastic Leukemia | Dana-Farber Cancer Institute / Jennifer Wu | Young Investigator Grants | 2012 | Massachusetts |
Selective inhibition of nuclear export as a novel therapeutic strategy in AML | Dana-Farber Cancer Institute / Julia Etchin | Young Investigator Grants | 2012 | Massachusetts |
Investigating the Role of the RNA Binding Protein LIN28 in Neuroblastoma | Boston Children’s Hospital / John Powers | Young Investigator Grants | 2012 | Massachusetts |
The Role of Mxi1 in the Modulation N-Myc Function in Neuroblastoma | Duke University / Michael Armstrong | Young Investigator Grants | 2011 | North Carolina |
Using zebrafish to model the molecular origins of pediatric myeloid malignancies and acute myeloid leukemia | Dana-Farber Cancer Institute / Evisa Gjini | Young Investigator Grants | 2011 | Massachusetts |
Targeting HMGA1 in Childhood ALL | The Johns Hopkins University School of Medicine / Amy M. Belton, PhD | Young Investigator Grants | 2011 | Maryland |
Mechanisms of Oncogenic Transformation by TLX1/HOX11 | University of Michigan / Mark Chiang | Young Investigator Grants | 2011 | Michigan |
Altering master genetic regulators SNF5/INI1 and LIN28A to model and treat atypical teratoid/rhabdoid tumors | The Johns Hopkins University School of Medicine / Eric Raabe | Young Investigator Grants | 2011 | Maryland |
Validation of microRNAs as valid targets in a pediatric sarcoma | University of Texas Southwestern Medical Center / Mark Hatley | Young Investigator Grants | 2011 | Texas |
Identification of Alveolar Rhabdomyosarcoma "Achilles' Heel" | National Cancer Institute / Fernanda Arnaldez | Young Investigator Grants | 2011 | Maryland |
Targeting the Mechanism of Differentiation Arrest in a Novel Model of Acute Leukemia | Massachusetts General Hospital / David Sykes | Young Investigator Grants | 2011 | Massachusetts |
Targeting polycomb-mediated epigenetic silencing in T cell acute lymphoblastic leukemia | Vanderbilt University Medical Center / Emmanuel Volanakis | Young Investigator Grants | 2011 | Tennessee |
Telomeres and Telomerase in Pediatric Acute Myeloid Leukemia | Baylor College of Medicine / Maria Gramatges | Young Investigator Grants | 2011 | Texas |
Investigation of Genetic and Molecular Mechanisms of Second Malignant Neoplasms in a Mouse Model | University of California San Francisco / Jean Nakamura | Young Investigator Grants | 2011 | California |
Engineering A Graft Versus Leukemia Effect into Cord Blood Transplant for Acute Lymphoblastic Leukemia | Fred Hutchinson Cancer Research Center / Rebecca Gardner | Young Investigator Grants | 2011 | Washington |
The Role of Metabolism in MLL-AF9 Leukemia Initiation | Massachusetts General Hospital / Rushdia Yusuf | Young Investigator Grants | 2010 | Massachusetts |
The role of PDE4B in Racial Disparities in Outcome of Childhood Acute Lymphoblastic Leukemia | St. Jude Children’s Research Hospital / Jun Yang | Young Investigator Grants | 2010 | Tennessee |
Identification and Characterization of an Epigenetic Program that Maintains the Self-Renewal of MLL Myeloid Leukemia Stem Cells | Stanford University / Hon-Kit Wong | Young Investigator Grants | 2010 | California |
Virotherapy on Primary Neuroblastoma Cells | Cincinnati Children's Hospital Medical Center / Pin-Yi Wang | Young Investigator Grants | 2010 | Ohio |
Characterization and Targeting of Novel Activating BRAF Mutations in Pediatric Brain Tumors | Children’s Hospital of Philadelphia / Angela Waanders, MD, MPH | Young Investigator Grants | 2010 | Pennsylvania |
Promoter Hypermethylation in MLL-Rearranged Leukemias: Biology and Therapeutic Targeting | The Johns Hopkins University School of Medicine / Eric Schafer | Young Investigator Grants | 2010 | Maryland |
TLE1 Tumor Suppressor as a Key Regulator of myc Induced Leukemia | Massachusetts General Hospital / Selvi Ramasamy | Young Investigator Grants | 2010 | Massachusetts |
MicroRNAs 100 and 125b in Ewing sarcoma | University of Colorado Denver / Paul Jedlicka | Young Investigator Grants | 2010 | Colorado |
Identification of Novel Treatment Targets by Exploring the Interaction of Rhabdomyosarcoma-Associated Oncogenes with Cellular Context in a Mouse Model of Rhabdomyosarcoma | Dana-Farber Cancer Institute / Simone Hettmer | Young Investigator Grants | 2010 | Massachusetts |
The p53-Mad2-Genomic Stability Pathway in the Development of Childhood Malignancies | Memorial Sloan-Kettering Cancer Center / Pascal Duijf | Young Investigator Grants | 2010 | New York |
The Role of DNA Methylation in Pediatric Cancer | Fred Hutchinson Cancer Research Center / Scott Diede | Young Investigator Grants | 2010 | Washington |
Single Cell Signaling Profiles In High-Risk Pediatric Leukemia | Stanford University / Kara Davis | Young Investigator Grants | 2010 | California |
Targeted Polymeric Parthenolide Carriers to Treat Childhood AML | University of Rochester / Danielle Benoit | Young Investigator Grants | 2010 | New York |
Optimizing EGFR targeted therapy in pediatric malignant glioma. | University of California San Francisco / Theodore Nicolaides | Young Investigator Grants | 2009 | California |
Identifying novel biomarkers for risk stratification in t-cell acute lymphoblastic leukemia (ALL). | University of California San Francisco / Michelle Hermiston, MD, PhD | Young Investigator Grants | 2009 | California |
Exploring a novel immunotherapy: cooperation of endogenous CD8+ t-cells and exogenous, allogeneic CD4+ t-cells. | The Johns Hopkins University School of Medicine / Heather Symons | Young Investigator Grants | 2009 | Maryland |
Identification of FDA approved drugs with anti-tumor activity in rhabdomyosarcoma. | Massachusetts General Hospital / David Langenau | Young Investigator Grants | 2009 | Massachusetts |
GSTM4, a novel target for treating Ewing sarcoma. | Huntsman Cancer Institute / Wen Luo | Young Investigator Grants | 2009 | Utah |
Aberrant DNA methylation in Ewing sarcoma. | Fred Hutchinson Cancer Research Center / Scott Borinstein | Young Investigator Grants | 2009 | Washington |
Genetic Regulators of ER Stress-induced Apoptosis in Pediatric Malignancies | Dana-Farber Cancer Institute / Ujwal Pyati | Young Investigator Grants | 2009 | Massachusetts |
Identification of proteins interacting with ALK in neuroblastoma. | Dana-Farber Cancer Institute / Rani George | Young Investigator Grants | 2009 | Massachusetts |
Immune Stimulatory Antigen Loaded Particles (ISAPS) for the Treatment of Solid Childhood Tumors | Children’s National Medical Center / Suzanne Miles | Young Investigator Grants | 2009 | District of Columbia |
MLL-based chromosomal translocations in the pathogenesis of childhood leukemia. | Children’s Mercy / Erin Guest | Young Investigator Grants | 2009 | Missouri |
DFMO-based combination therapy for the treatment of advanced stage neuroblastoma. | Cancer Research Center of Hawaii / Dana-Lynn Koomoa | Young Investigator Grants | 2009 | Hawaii |
Immunotherapeutic Targeting of Stem Cells in Pediatric Brain Tumors | Harbor - UCLA Medical Center / Joseph Lasky | Young Investigator Grants | 2008 | California |
Untangling the Matrix in Medulloblastoma | St. Christopher's Hospital for Children / Duncan Stearns, MD | Young Investigator Grants | 2008 | Ohio |
Characterization and Targeting of p53 Ubiquitination in Neuroblastoma. | Baylor College of Medicine / Eveline Barbieri, MD, PhD | Young Investigator Grants | 2008 | Texas |
The TC3 Line, a Zebrafish Model of T-Cell Malignancy | Huntsman Cancer Institute / Nathan Meeker, MD | Young Investigator Grants | 2008 | Utah |
Genomic Alterations in Medulloblastoma | Children’s Hospital Los Angeles / Shahab Asgharzadeh, MD | Young Investigator Grants | 2008 | California |
A mouse model of Wilms' Tumor | Massachusetts General Hospital / Nabeel Bardeesy, PhD | Young Investigator Grants | 2008 | Massachusetts |
MDM2 as an Effector of Hedgehog Signaling in Brain Development and Medulloblastoma | Purdue University / Susan Mendrysa, PhD | Young Investigator Grants | 2008 | Indiana |
Reciprocal interactions between tumor killer dendritic cells and tumor-induced regulatory T lymphocytes | University of Arizona / Nicolas Larmonier, PhD | Young Investigator Grants | 2008 | Arizona |
Integration of Targeted New Agents with Chemotherapy | Children’s Hospital of Philadelphia / Robin Norris, MD | Young Investigator Grants | 2008 | Pennsylvania |
Targeting HMGA1 in Pediatric T-cell Acute Lymphoblastic Leukemia | The Johns Hopkins University School of Medicine / Joelle Hillion, PhD | Young Investigator Grants | 2008 | Maryland |
Development of Immunostimulatory DNA as a Novel Therapy in Pediatric Acute Lymphoblastic Leukemia | Children’s Hospital of Philadelphia / Alix Seif, MD, MPH | Young Investigator Grants | 2008 | Pennsylvania |
Treatment of high-risk pediatric brain tumors with a CD133-targeted adenovirus in combination with temozolomide | University of Texas M.D. Anderson Cancer Center / Marta Alonso, PhD | Young Investigator Grants | 2008 | Texas |
Identification and Validation of Differentiation Therapy for Osteosarcoma | Dana-Farber Cancer Institute / Katherine Janeway, MD | Young Investigator Grants | 2008 | Massachusetts |
The Role of PASG in Mediating Epigenetic Change and Outcome in AML. | The Johns Hopkins University School of Medicine / Jason Farrar, MD | Young Investigator Grants | 2007 | Maryland |
E2A translocations in pediatric leukemia: developing new therapeutic targets | Children’s Hospital of Philadelphia / Bruce Fischer, MD | Young Investigator Grants | 2007 | Pennsylvania |
Mechanisms of regulation of the PI#K/AKT pathway downstream of NOTCH1 in T-ALL. | Columbia University / Teresa Palomero, PhD | Young Investigator Grants | 2007 | New York |
DNA methylation in medulloblastoma | University of Colorado Denver / Rajeev Vibhakar, MD, PhD, MPH | Young Investigator Grants | 2007 | Colorado |
Resistance to anti-angiogenic therapy in pediatric solid tumors. | Feinstein Institute for Medical Research - North Shore / Samuel Soffer, MD | Young Investigator Grants | 2007 | New York |
The Role of Inhibition of Apoptosis by C/EBPalpha and C/EBPalpha oncoproteins in AML. | The Johns Hopkins University School of Medicine / Ido Paz-Priel, MD | Young Investigator Grants | 2007 | Maryland |
Developing an accurate genetic model for rhabdomyosarcoma therapy | Children’s Research Institute / Dawn Chandler, PhD | Young Investigator Grants | 2007 | District of Columbia |
The Identification of Neuroblastoma Cancer Stem Cells. | Stanford University / Robert Cho | Young Investigator Grants | 2007 | California |
Generation of a novel oncolytic virus for treatment of pediatric brain tumors. | The Ohio State University / Balveen Kaur, PhD | Young Investigator Grants | 2007 | Ohio |
Immunotherapy for Osteosarcoma and Ewing sarcoma | Baylor College of Medicine / Nabil Ahmed, MD, MSc | Young Investigator Grants | 2007 | Texas |
An Exploration of the Medulloblastoma and Glioblastoma Genomes: A Critical Analysis of Candidate Cancer Genes as Potential Molecular Targets for Diagnostics and Therapeutics | The Johns Hopkins University School of Medicine / Will Parsons, MD, PhD | Young Investigator Grants | 2007 | Maryland |
Research Institute at Nationwide Children's Hospital / Mary Beth Ross, MD/PhD | Young Investigator Grants | 2006 | Ohio | |
Mediators of Metastasis in Alveolar Rhabdomyosarcoma. | University of Texas Health Science Center at San Antonio / Koichi Nishijo, MD, PhD | Young Investigator Grants | 2006 | Texas |
WIP1 Modulates Responsiveness of MB to Genotoxic Stress. | Aflac Cancer Center and Blood Disorders Service of Children’s Healthcare of Atlanta / Robert Craig Castellino, MD | Young Investigator Grants | 2006 | Georgia |
Mechanisms of leukocyte recruitment to the lung during idiopathic pneumonia syndrome following allogeneic bone marrow transplantation. | Regents of the University of Michigan / Sung Won Choi, MD | Young Investigator Grants | 2006 | Michigan |
Hedgehog & IGF Signaling through IRSI in Brain Development and Medulloblastoma | Memorial Sloan-Kettering Cancer Center / Anna Marie Kenney, PhD | Young Investigator Grants | 2006 | New York |
MTG-16 Regulation by Phosphorylation | Vanderbilt University Medical Center / Michael Engel, MD, PhD | Young Investigator Grants | 2006 | Tennessee |
Assess the activity of ABT-737 as a single agent against neuroblastoma cell lines grown in cell culture | Children’s Hospital Los Angeles / Theresa Harned, MD | Young Investigator Grants | 2006 | California |
Pax3-FKHR targets that enable bypass of cellular senescence in rhabdomyosarcoma. | Duke University Medical Center / Corinne Mary Linardic, MD, PhD | Young Investigator Grants | 2006 | North Carolina |
Anti-Angiogenic Effects of BAI Proteins in Neuroblastoma | Children’s Hospital of Philadelphia / Naomi Balamuth, MD | Young Investigator Grants | 2006 | Pennsylvania |
Modeling osteosarcoma to identify novel therapeutic targets. | Stanford University / Julien Sage | Young Investigator Grants | 2006 | California |