ALSF Childhood Cancer Research Grants
With your support, we have been able to fund outstanding research, leading toward cures and improved quality of life for children with cancer. Browse through more than 1,500 funded projects below.
Use the search tool to refine your results. You can also click on a heading to sort by project title, institution name, or year the grant was awarded. Click on the project title to read more information.
You can learn about ALSF's grant review process here.
ALSF Funded Research Projects
| Project Title | Institution / Principal Investigator(s) | Grant Type | Year | State |
|---|---|---|---|---|
| Modulation of STING to enhance the efficacy of treatments for diffuse midline glioma | Duke University / Zachary Reitman, MD/PhD | 'A' Award Grants | 2023 | North Carolina |
| Uncovering the signaling mechanisms allowing medulloblastoma progenitor cells to orchestrate tumor relapse | Medical University of South Carolina / Jezabel Rodriguez Blanco, PhD | 'A' Award Grants | 2023 | South Carolina |
| A Cell Morphology Landscape of Pediatric Cancer Cell Lines | University of Colorado Denver_ Anschutz Medical Campus / Gregory Way, PhD | 'A' Award Grants | 2023 | Colorado |
| Unraveling the Function of PAX3-FOXO1’s Activation Domain in Rhabdomyosarcoma | Case Western Reserve University / Berkley Gryder, PhD | 'A' Award Grants | 2023 | Ohio |
| The Role of the Innate Immune System in Immune Dysregulation following CART | Children’s Hospital of Philadelphia / Caroline Diorio, MD | 'A' Award Grants | 2023 | Pennsylvania |
| Genomic and nuclear organizational changes in chemotherapy-resistant rhabdomyosarcoma cells | Ann & Robert H. Lurie Children’s Hospital of Chicago / Kyle MacQuarrie, MD/PhD | 'A' Award Grants | 2023 | Illinois |
| Characterizing the Developmental Context of Pediatric Leukemia | Icahn School of Medicine at Mount Sinai / Elvin Wagenblast, PhD | 'A' Award Grants | 2022 | New York |
| Targeting Kinase Inhibitor Induced DNA-Damage Response in Ph-Like ALL | Temple University / Christian Hurtz, PhD | 'A' Award Grants | 2022 | Pennsylvania |
| Exploiting glypican diversity in neuroblastoma plasticity with bicistronic CAR T cell targeting | Children’s Hospital of Philadelphia / Kristopher Bosse, MD | 'A' Award Grants | 2022 | Pennsylvania |
| Turning Killers into THINKers: TME Hostility-Impervious NK Cells for Treating Neuroblastoma and Sarcoma | Baylor College of Medicine / Robin Parihar, MD/PhD | 'A' Award Grants | 2021 | Texas |
| Circulating Tumor Biomarkers: New Paradigms for Management of Neuroblastoma | University of Chicago / Mark Applebaum, PhD | 'A' Award Grants | 2021 | Illinois |
| The Interplay Between Histone Mutations and Replication Stress in Shaping Glioma Phenotypes | Dana-Farber Cancer Institute / Pratiti Bandopadhayay, PhD | 'A' Award Grants | 2021 | Massachusetts |
| Synergistic Activity of Anti-GD2 Antibody and CD47-Blockade for Immunotherapy of Neuroblastoma and Osteosarcoma | The Board of Trustees of the Leland Stanford Junior University / Robbie Majzner, MD | 'A' Award Grants | 2019 | California |
| Elucidating the Role of SETD2 in Pediatric High Grade Glioma Formation | Children’s Hospital of Philadelphia / Thomas De Raedt, PhD | 'A' Award Grants | 2019 | Pennsylvania |
| Exploiting the Differentiation Potential of Pediatric High-Grade Glioma to Discover Novel Therapeutic Opportunities | Dana-Farber Cancer Institute / Mariella Filbin, MD/PhD | 'A' Award Grants | 2019 | Massachusetts |
| The Role of Pyruvate Dehydrogenase in Leukemia | University of Texas Southwestern Medical Center at Dallas / Michalis Agathocleous, PhD | 'A' Award Grants | 2018 | Texas |
| Mechanisms of PAX3-FOXO1 and HES3 Cooperation in Rhabdomyosarcoma | Nationwide Children’s Hospital / Genevieve Kendall, PhD | 'A' Award Grants | 2018 | Ohio |
| Functional Characterization of RELA Fusion Ependymoma as a Basis for Therapeutic Targeting | St. Jude Children’s Research Hospital / Stephen Mack, PhD | 'A' Award Grants | 2018 | Tennessee |
| Novel Approaches to AML Differentiation Therapy | Dana-Farber Cancer Institute / Andrew Lane, MD/PhD | 'A' Award Grants | 2017 | Massachusetts |
| Reversing mSWI/SNF (BAF) Complex Misassembly and Genomic Targeting in Human Synovial Sarcoma | Dana-Farber Cancer Institute / Cigall Kadoch, PhD | 'A' Award Grants | 2017 | Massachusetts |
| Role of Primary Cilium Signaling and Dynamics in Medulloblastoma Initiation and Progression | University of Texas Southwestern Medical Center / Saikat Mukhopadhyay, MD/PhD | 'A' Award Grants | 2016 | Texas |
| The Role of Inherited MLL3 Single Nucleotide Variants and Fetal Epigenetic Programming in Infant Leukemogenesis | Washington University / Jeffrey Magee, MD/PhD | 'A' Award Grants | 2016 | Missouri |
| Uncovering the Dysregulated RNA Binding Protein Network in Childhood Acute Myeloid Leukemia | Memorial Sloan-Kettering Cancer Center / Michael Kharas, PhD | 'A' Award Grants | 2016 | New York |
| Engineering the CAR T Cells to Overcome Tumor Derived Immune-Inhibition in Glioblastoma | Baylor College of Medicine / Meenakshi Hegde, MD | 'A' Award Grants | 2016 | Texas |
| An Engineered Nanoimmunotherapy for Treating Neuroblastoma | George Washington University / Rohan Fernandes, PhD | 'A' Award Grants | 2016 | District of Columbia |
| Inside-Out Immunotherapy: Combating Neuroblastoma via Nanoparticle-Directed Reprogramming of the Tumor Microenvironment | Vanderbilt University Medical Center / John Wilson, PhD | 'A' Award Grants | 2015 | Tennessee |
| Targeting the LIN28 Pathway in ATRT | The Johns Hopkins University School of Medicine / Eric Raabe, MD, PhD | 'A' Award Grants | 2015 | Maryland |
| Genetically Modified, Cord Blood Derived Natural Killer Cell Therapy for High Grade Pediatric Brain Tumors | Children’s Research Institute / Conrad Russell Cruz, MD, PhD | 'A' Award Grants | 2015 | District of Columbia |
| Genetic Susceptibility to Pediatric Osteosarcoma and Interaction with Measures of Childhood Growth | Duke University / Kyle Walsh, Ph.D. | 'A' Award Grants | 2014 | North Carolina |
| Investigating the Role of Genetic and Epigenetic Variation in Risk of Childhood Acute Lymphoblastic Leukemia in Down Syndrome | University of California San Francisco / Adam de Smith, Ph.D. | 'A' Award Grants | 2014 | California |
| The Role of MST1 in Non-canonical Hippo Signaling in Rhabdomyosarcoma | Duke University / Lisa Crose, Ph.D. | 'A' Award Grants | 2014 | North Carolina |
| Rational Combination Therapy of AML | Memorial Sloan-Kettering Cancer Center / Alex Kentsis, MD, PhD | 'A' Award Grants | 2013 | New York |
| Targeting Metabolism in Alveolar Soft Part Sarcomagenesis | Huntsman Cancer Institute / Kevin Jones, MD | 'A' Award Grants | 2013 | Utah |
| IDO-based Immunotherapy for Pediatric Brain Tumors | Georgia Health Sciences University Research Institute, Inc. / Theodore Johnson, MD, PhD | 'A' Award Grants | 2013 | Georgia |
| Engineering the Lymph Node Environment with Therapeutic Vaccine Depots to Combat Neuroblastoma | University of Maryland, College Park / Christopher Jewell, PhD | 'A' Award Grants | 2013 | Maryland |
| DNA Damage Responses Coordinate Survival and Cell Death Switching In Lymphocytes | Washington University / Jeffrey Bednarski, MD, PhD | 'A' Award Grants | 2013 | Missouri |
| Prognostic and Therapeutic Significance of Stem Cell Heterogeneity in AML | Fred Hutchinson Cancer Research Center / Roland Walter, MD, PhD | 'A' Award Grants | 2012 | Washington |
| BET Bromodomain Inhibition as Epigenetic Therapy in Pediatric Leukemia | Cold Spring Harbor Laboratory / Christopher Vakoc, MD, PhD | 'A' Award Grants | 2012 | New York |
| A Role for Notch in Self-renewal in Embryonal Rhabdomyosarcoma | Massachusetts General Hospital / Myron Ignatius, PhD | 'A' Award Grants | 2012 | Massachusetts |
| Epigenetic Modifiers as Therapeutic Targets in Pediatric T-cell Acute Lymphoblastic Leukemia | Washington University / Grant Challen, PhD | 'A' Award Grants | 2012 | Missouri |
| A Combinatorial Approach to Target the Tumor-Initiating and Transit Amplifying Cellular Subpopulations in Diffuse Intrinsic Pontine Glioma (DIPG) | Stanford University / Michelle Monje, MD, PhD | 'A' Award Grants | 2011 | California |
| Blockade of p53 and Aurora A in Therapy Resistant Neuroblastoma | University of California San Francisco / William Clay Gustafson, MD, PhD | 'A' Award Grants | 2011 | California |
| Pediatric Sarcoma, Rhabdomyosarcoma, and Mechanisms of Origin | University of Texas Southwestern Medical Center / Rene Galindo | 'A' Award Grants | 2010 | Texas |
| Identifying Rare Genetic Variants Involved in High Risk Pediatric Leukemia Via Pooled Sequencing | Washington University / Todd Druley, MD, PhD | 'A' Award Grants | 2009 | Missouri |
| Genetic Analysis of Pediatric Gliomas | Baylor College of Medicine / Will Parsons, MD, PhD | 'A' Award Grants | 2009 | Texas |
| WWOX as a Signal Mediator in Pediatric Osteosarcoma | The Ohio State University / Rami Aqeilan | 'A' Award Grants | 2009 | Ohio |