Studies on the Growth-suppressive Mechanism of PID1 in Childhood Medulloblastoma

Background

Due to the low cure rates and the many long-term effects of treatment for those cured the tumors of medulloblastoma take many lives each day. There is not enough good research and understanding of medulloblastoma biology to develop better therapies with less long term consequences.

Project Goal

Gabriel will be working with the laboratory that first discovered PID1, the gene that has growth-suppressive effects in medulloblastomas. They will be working to understand the molecular mechanisms that mediate the gene. Their long-term goal is to determine the region that causes medulloblastoma in the protein made by PID1, and to develop cell-permeable molecular mimics of a small portion of the protein into a new drug to fight medulloblastomas.