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Translational Utility of New Models of Human AML

Institution: 
Cincinnati Children's Hospital Medical Center
Researcher(s): 
Benjamin Kleeman
Grant Type: 
POST Program Grants
Year Awarded: 
2017
Type of Childhood Cancer: 
Acute Myeloid Leukemia (AML)
Project Description: 

Background

Acute myeloid leukemia (AML) is a genetically complex group of cancers wherein pediatric patients can be divided into those with chromosomal translocations and patients that are cytogenetically normal (CN-AML). Murine models for AMLs other than CN-AML have been effective in representing the somatic mutations found in humans. CN-AML modeling, however, has been less successful. With nearly 50% of human AML cases represented by CN-AML, there exists a serious need for genetically validated animal models to address pressing biological and therapeutic questions.

Project Goal

The Grimes lab has generated a rapid, spontaneous and accurate mouse model of human CN-AML, and plan to use this model to determine the translational utility of murine Flt3-ITD Dnmt3a AML compared to AML models generated with AML-ETO and MLL-AF9 translocation leukemia oncoproteins.

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Arianna is a firecracker. She is loving, empathetic, and bold. At a mere 13 months old, Arianna was diagnosed with neuroblastoma and began intensive treatment with some life-threatening complications. Today she is NED and her family raises money for ALSF.
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