Neuroblastoma is the most frequently diagnosed cancer in infancy, comprises more than 7% of cancers in patients younger than 15 years of age, and is responsible for 15% of all childhood cancer deaths. There remains a need for novel treatment strategies to eliminate residual disease resistant to current therapies. We will study if natural killer (NK) cells, an important cell in our immune system, and the immune genes responsible for their behavior play a role in the control and eradication of neuroblastoma.